SERPINA12 Protein (AA 21-414) (GST tag)

N° du produit ABIN1097502

Détail du produit

Antigène: SERPINA12 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 12 (SERPINA12))

Type de proteíne: Recombinant

Attributs du protein: AA 21-414

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette SERPINA12 protéine est marqué à la GST tag.

Fonction: Recombinant Human Serpin A12/Vaspin (N-GST)

Séquence: MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD LVPRGSLKPS FSPRNYKALS EVQGWKQRMA AKELARQNMD LGFKLLKKLA FYNPGRNIFL SPLSISTAFS MLCLGAQDST LDEIKQGFNF RKMPEKDLHE GFHYIIHELT QKTQDLKLSI GNTLFIDQRL QPQRKFLEDA KNFYSAETIL TNFQNLEMAQ KQINDFISQK THGKINNLIE NIDPGTVMLL ANYIFFRARW KHEFDPNVTK EEDFFLEKNS SVKVPMMFRS GIYQVGYDDK LSCTILEIPY QKNITAIFIL PDEGKLKHLE KGLQVDTFSR WKTLLSRRVV DVSVPRLHMT GTFDLKKTLS YIGVSKIFEE HGDLTKIAPH RSLKVGEAVH KAELKMDERG TEGAAGTGAQ TLPMETPLVV KIDKPYLLLI YSEKIPSVLF LGKIVNPIGK

Attributs du produit: Recombinant Human Serpin A12 is produced by our E. coli expression system. The target protein is expressed with sequence (Leu21-Lys414) of Human Serpin A12 fused with a GST tag at the N-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Supplied as a 0.2 μm filtered solution of 50 mM TrisHCl, 160 mM NaCl, 0.2 mM PMSF, 1 mM DTT, 10 % Glycerine, pH 7.2 .

Agent conservateur: Dithiothreitol (DTT)

Précaution d'utilisation: This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Stock: -80 °C

Stockage commentaire: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Date de péremption: 6 months

Détail du antigène

Antigène: SERPINA12 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 12 (SERPINA12))

Autre désignation: Serpin A12 (SERPINA12 Produits)

Synonymes: SERPINA12 Protein, 4632419J12Rik Protein, OL-64 Protein, Ol-64 Protein, Ol64 Protein, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 Protein, serpin family A member 12 Protein, serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 Protein, serpin A12 Protein, SERPINA12 Protein, Serpina12 Protein, LOC612386 Protein

Sub Type: Fusionprotein

Sujet: Vaspin (Visceral Adipose-Specific SERPIN) is a newly described adipokine. Vaspin has three beta-sheets, nine alpha-helices, and one central loop, the structure is part of the set of distinctive features that are descriptive of Serpin family members. Vaspin is also a unique insulin sensitizing adipocytokine in obesity. A recent publication indicates that Vaspin mRNA expression in visceral fat is positively correlated with BMI and percent of body fat. and could be associated with parameters of obesity, insulin resistance, and glucose metabolism. These findings suggest a potential clinical use for Vaspin in ameliorating certain aberrations seen in the obesity metabolic syndrome.
Alternative Names: Serpin A12, OL-64, Visceral Adipose Tissue-Derived Serine Protease Inhibitor, Vaspin, Visceral Adipose-Specific Serpin, SERPINA12

Poids moléculaire: 71.4 kDa

UniProt: Q8IW75