SERPINA5 Protein (AA 20-406) (His tag)

N° du produit ABIN1097511

Détail du produit

Antigène: SERPINA5 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 5 (SERPINA5))

Type de proteíne: Recombinant

Attributs du protein: AA 20-406

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette SERPINA5 protéine est marqué à la His tag.

Fonction: Recombinant Human Serpin A5/Protein C Inhibitor (C-6His)

Séquence: HRHHPREMKK RVEDLHVGAT VAPSSRRDFT FDLYRALASA APSQNIFFSP VSISMSLAML SLGAGSSTKM QILEGLGLNL QKSSEKELHR GFQQLLQELN QPRDGFQLSL GNALFTDLVV DLQDTFVSAM KTLYLADTFP TNFRDSAGAM KQINDYVAKQ TKGKIVDLLK NLDSNAVVIM VNYIFFKAKW ETSFNHKGTQ EQDFYVTSET VVRVPMMSRE DQYHYLLDRN LSCRVVGVPY QGNATALFIL PSEGKMQQVE NGLSEKTLRK WLKMFKKRQL ELYLPKFSIE GSYQLEKVLP SLGISNVFTS HADLSGISNH SNIQVSEMVH KAVVEVDESG TRAAAATGTI FTFRSARLNS QRLVFNRPFL MFIVDNNILF LGKVNRPVDH HHHHH

Attributs du produit: Recombinant Human Serpin A5 produced by transfected human cells is a secreted protein with sequence (His20-Pro406) of Human SERPINA5 fused with a polyhistidine tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM MES, 150 mM NaCl, pH 5.5.

Conseil sur la manipulation: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Stock: 4 °C/-20 °C/-80 °C

Stockage commentaire: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 3 months

Détail du antigène

Antigène: SERPINA5 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 5 (SERPINA5))

Autre désignation: protein-c-inhibitor (SERPINA5 Produits)

Synonymes: 4933415L04 Protein, PAI-3 Protein, Pci Protein, PAI3 Protein, PCI Protein, PCI-B Protein, PLANH3 Protein, PROCI Protein, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 Protein, serpin family A member 5 Protein, serine (or cysteine) peptidase inhibitor, clade A, member 5 Protein, plasma serine protease inhibitor Protein, SPIA5 Protein, SERPINA5 Protein, Serpina5 Protein, LOC480424 Protein

Sub Type: Fusionprotein

Sujet: Serpin A5 is a member of the human Serpin superfamily consists of at least 35 members. It is synthesized in the liver and has been detected in saliva, cerebral spinal fluid, amniotic fluid, tears and semen. As a potent inhibitor of the protein C anticoagulant pathway at the levels of both zymogen activation and enzyme inhibition, Serpin A5 additionally inhibits a variety of serine protease including thrombin, factor Xa, several kallekreins and acrosin. It plays a critical role in the processes of blood of blood coagulation and fertilization. Serpin A5 also inhibits urinary plasminogen activator (uPA), a mediator of tumor cell invasion, and regulates tumor growth and metastasis by inhibiting angiogenesis. Furthermore, recent studies have identified PCI as a potent and direct inhibitor of activated HGFA (hepatocyte growth factor activator), suggesting a novel function in the regulation of tissue repair and regeneration. Similar to Serpins C1 and D1, the thrombin inhibitory activity of serpinA5 is enhanced by heparin.
Alternative Names: Plasma Serine Protease Inhibitor, Acrosomal Serine Protease Inhibitor, Plasminogen Activator Inhibitor 3, PAI-3, PAI3, Protein C Inhibitor, PCI, Serpin A5, SERPINA5, PCI, PLANH3, PROCI

Poids moléculaire: 44.7 kDa

UniProt: P05154