SERPINA7 Protein (AA 21-415) (His tag)

N° du produit ABIN1097517

Détail du produit

Antigène: SERPINA7 (Serpin Family A Member 7 (SERPINA7))

Type de proteíne: Recombinant

Attributs du protein: AA 21-415

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette SERPINA7 protéine est marqué à la His tag.

Fonction: Recombinant Human Serpin A7/TBG (C-6His)

Séquence: ASPEGKVTAC HSSQPNATLY KMSSINADFA FNLYRRFTVE TPDKNIFFSP VSISAALVML SFGACCSTQT EIVETLGFNL TDTPMVEIQH GFQHLICSLN FPKKELELQI GNALFIGKHL KPLAKFLNDV KTLYETEVFS TDFSNISAAK QEINSHVEMQ TKGKVVGLIQ DLKPNTIMVL VNYIHFKAQW ANPFDPSKTE DSSSFLIDKT TTVQVPMMHQ MEQYYHLVDM ELNCTVLQMD YSKNALALFV LPKEGQMESV EAAMSSKTLK KWNRLLQKGW VDLFVPKFSI SATYDLGATL LKMGIQHAYS ENADFSGLTE DNGLKLSNAA HKAVLHIGEK GTEAAAVPEV ELSDQPENTF LHPIIQIDRS FMLLILERST RSILFLGKVV NPTEAVDHHH HHH

Attributs du produit: Recombinant Human Serpin A7 produced by transfected human cells is a secreted protein with sequence (Ala21-Ala415) of human SERPIN A7 fused with a polyhistidine tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, 5 % Threhalose, pH 7.2.

Conseil sur la manipulation: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Stock: 4 °C/-20 °C/-80 °C

Stockage commentaire: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 3 months

Détail du antigène

Antigène: SERPINA7 (Serpin Family A Member 7 (SERPINA7))

Autre désignation: t4-binding-globulin (SERPINA7 Produits)

Synonymes: C730040N12Rik Protein, Tbg Protein, TBG Protein, THYROXINE-BINDING GLOBULIN Protein, serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 Protein, serpin family A member 7 Protein, Serpina7 Protein, SERPINA7 Protein

Sub Type: Fusionprotein

Sujet: Serpin A7 is a secreted protein which belongs to the Serpin family. As a 54 kDa protein, Serpin A7 is synthesized primarily in the liver and secreted in plasma. Genomically, Serpin A7 is a serpin, although it has no inhibitory function like many other members of this class of proteins. Serpin A7 binds thyroid hormone in circulation. It is one of three proteins (along with transthyretin and albumin) responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3’-triiodothyronine (T3) in the bloodstream. Of these three proteins, Serpin A7 has the highest affinity for T4 and T3, but is present in the lowest concentration. Despite its low concentration, Serpin A7 carries the majority of T4 in serum. Due to the very low serum concentration of T4 and T3 in the blood, Serpin A7 is rarely more than 25% saturated with its ligand. Unlike transthyretin and albumin, Serpin A7 has a single binding site for T4/T3. Serpin A7 tests are sometimes used in finding the reason for elevated or diminished levels of thyroid hormone, and defects in Serpin A7 are a cause of Serpin A7 deficiency.
Alternative Names: Thyroxine-Binding Globulin, Serpin A7, T4-Binding Globulin, SERPINA7, TBG

Poids moléculaire: 45.14 kDa

UniProt: P05543

Pathways: Hormone Transport