ULBP1 Protein (His tag)

N° du produit ABIN1098403

Détail du produit

Antigène: ULBP1 (UL16 Binding Protein 1 (ULBP1))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette ULBP1 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Purification: purified by chromatography

Pureté: > 90 % by SDS - PAGE

Information d'application

Commentaires:

Synonyms: NKG2D ligand 1, UL16 binding protein 1, RAET1I, N2DL-1, N2DL1, NKG2D ligand 1

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/ml (determined by Bradford assay)

Buffer: 20 mM Tris-HCl buffer (pH 8.0) containing 0.15 M NaCl, 30% glycerol, 1 MM DTT

Stock: 4 °C

Stockage commentaire: Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: ULBP1 (UL16 Binding Protein 1 (ULBP1))

Autre désignation: ULBP1 (ULBP1 Produits)

Synonymes: RAET1I Protein, A430108B07Rik Protein, MULT1 Protein, ULBP1 Protein, UL16 binding protein 1 Protein, UL16 binding protein 21 Protein, NKG2D ligand 1 Protein, ULBP1 Protein, ULBP21 Protein, Ulbp1 Protein, LOC100683099 Protein

Sujet: ULBP1 is ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. In CMV infected cells, ULBP1 interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. Recombinant human ULBP1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Poids moléculaire: 25 kDa (216aa) confirmed by MALDI-TOF

NCBI Accession: NP_079494

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process