DEDD Protein (His tag)

N° du produit ABIN7280134

Détail du produit

Antigène: DEDD (Death Effector Domain Containing (DEDD))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette DEDD protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Pureté: > 85 % by SDS - PAGE

Information d'application

Commentaires:

Synonyms: Death effector domain-containing protein, CASP8IP1, DEDD1, DEFT, FLDED1, KE05

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/ml (determined by Bradford assay)

Buffer: 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea, 10% glycerol

Stock: 4 °C

Stockage commentaire: Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: DEDD (Death Effector Domain Containing (DEDD))

Autre désignation: DEDD (DEDD Produits)

Synonymes: CASP8IP1 Protein, DEDD1 Protein, DEFT Protein, FLDED1 Protein, Dedpro1 Protein, KE05 Protein, Deft Protein, death effector domain containing Protein, death effector domain-containing Protein, DEDD Protein, Dedd Protein

Sujet: Death effector domain-containing protein, also known as DEDD, is a cytoplasmic protein. It translocates to the nucleus during CD95-mediated apoptosis, where it localizes to nucleoli-like structures, activates caspase-6 and specifically inhibits RNA polymerase I-dependent transcription. The cell death activity of DEDD relates to its nuclear localization. DEDD is widely expressed in a variety of tissues, with highest levels in the testis. Overexpression of this gene was shown to induce weak apoptosis. Recombinant human DEDD protein, fused to His-tag at N-terminus, was expressed in E.coli.

Poids moléculaire: 38.9 kDa (338aa)

NCBI Accession: NP_127491