IL-1 beta Protein (AA 117-269)
Aperçu rapide pour IL-1 beta Protein (AA 117-269) (ABIN1343987)
Antigène
Voir toutes IL-1 beta (IL1B) ProtéinesType de proteíne
Activité biologique
Origine
Source
Application
Pureté
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Attributs du protein
- AA 117-269
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Fonction
- IL-1beta (human) (rec.) (untagged)
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Specificité
- Binds to human IL-1R.
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Réactivité croisée
- Humain
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Attributs du produit
- Human IL-1beta (aa 117-269) is untagged.
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niveau d'endotoxine
- <0.1EU/μg purified protein (LAL test).
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Biological Activity Comment
- Activates the NF-kappaB with an ED50 of <5ng/ml.
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Interleukin 1, beta (IL1B) (AA 117-269) protein (His-Avi Tag)
IL1B Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by SEC-HPLC
Interleukin 1, beta (IL1B) (AA 117-269) (Active) protein (Biotin,His-Avi Tag)IL1B Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Interleukin 1, beta (IL1B) (AA 1-269) protein (GST tag)IL1B Origine: Humain Hôte: Wheat germ Recombinant WB, ELISA, AA, AP
Interleukin 1, beta (IL1B) (AA 117-269) protein (Fc Tag)IL1B Origine: Humain Hôte: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 1, beta (IL1B) (AA 106-267) protein (His tag)IL1B Origine: Poulet Hôte: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Interleukin 1, beta (IL1B) (AA 114-266) protein (His tag)IL1B Origine: Chévre Hôte: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Interleukin 1, beta (IL1B) (AA 115-266) protein (His tag)IL1B Origine: Chien Hôte: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Interleukin 1, beta (IL1B) (AA 115-267) protein (His tag)IL1B Origine: Porc Hôte: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Interleukin 1, beta (IL1B) (AA 116-268) protein (His tag)IL1B Origine: Cheval Hôte: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Interleukin 1, beta (IL1B) (AA 170-269) protein (GST tag)IL1B Origine: Humain Hôte: Wheat germ Recombinant WB, ELISA, AA, AP
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Indications d'application
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstitute with 100 μL sterile water.
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Concentration
- 0.1 mg/mL
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Buffer
- Contains PBS.
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Conseil sur la manipulation
- After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1 % BSA should be used for further dilutions.
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Stock
- 4 °C,-20 °C
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Stockage commentaire
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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Date de péremption
- 6 months
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- IL-1 beta (IL1B) (Interleukin 1, beta (IL1B))
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Autre désignation
- IL-1beta
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Sujet
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Interleukin-1beta, IL-1F2
IL-1beta is produced by activated macrophages. IL-1beta stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1beta belongs to the IL-1 family of proteins that are involved in the inflammatory response. IL-1beta in most situations requires the inflammasome complex to be cleaved and secreted.
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Poids moléculaire
- ~17kDa (SDS-PAGE)
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UniProt
- P01584
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Pathways
- Signalisation NF-kappaB, Interferon-gamma Pathway, Signalisation TLR, Negative Regulation of Hormone Secretion, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Autophagy, Cancer Immune Checkpoints, Inflammasome
Antigène
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