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IL-37 Protein (AA 46-218) (His tag)

IL37 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant >95 % (SDS-PAGE) SDS
N° du produit ABIN1344168
  • Antigène Voir toutes IL-37 (IL37) Protéines
    IL-37 (IL37) (Interleukin 37 (IL37))
    Type de proteíne
    Recombinant
    Attributs du protein
    AA 46-218
    Origine
    Humain
    Source
    • 7
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Purification/Conjugué
    Cette IL-37 protéine est marqué à la His tag.
    Application
    SDS-PAGE (SDS)
     Réactivité croisée
    Humain
    Attributs du produit
    Human IL-37 (aa Val46-Asp218) is fused at the C-terminus to a His-tag.
    Pureté
    >95 % (SDS-PAGE)
    Stérilité
    0.2 μm filtered
    niveau d'endotoxine
    <0.1EU/μg purified protein (LAL test, Lonza).
    Top Product
    Discover our top product IL37 Protéine
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstitute in distilled water.
    Concentration
    Lot specific
    Buffer
    Lyophilized from 0.2μm-filtered solution in 55 mM TRIS-Cl, pH 8.2, containing 150 mM NaCl.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
    Date de péremption
    6 months
  • Antigène
    IL-37 (IL37) (Interleukin 37 (IL37))
    Autre désignation
    IL-37 (IL37 Produits)
    Synonymes
    FIL1 Protein, FIL1(ZETA) Protein, FIL1Z Protein, IL-1F7 Protein, IL-1H Protein, IL-1H4 Protein, IL-1RP1 Protein, IL-37 Protein, IL1F7 Protein, IL1H4 Protein, IL1RP1 Protein, interleukin 37 Protein, IL37 Protein
    Sujet
    IL-37 (IL-1F7, IL-1H4) is an IL-1 family member that is expressed only in certain types of human organs and cells such as heart, thymus, testis, kidney, mononuclear cells (PBMCs) and dendritic cells. IL-37 is an inhibitor of innate immunity with anti-inflammatory properties. It binds to the interleukin-18 receptor (IL-18R) and its co-receptor SIGIRR. IL-37 is secreted as a full-length and as a processed form starting from amino acid Val46. It plays an important role as a link between innate and adaptive immunity and acts as an inhibitor of autoimmune diseases and tumor growth. IL-37 also inhibited Lipopolysaccharide (LPS)-induced immunological reaction and LPS-induced osteoclast formation and bone resorption.
    Poids moléculaire
    ~20kDa (SDS-PAGE)
    UniProt
    Q9NZH6
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