FGF4 Protéine

N° du produit ABIN1589633

Cette protéine Recombinant FGF4 est produite dans Escherichia coli (E. coli).

Aperçu rapide pour FGF4 Protéine (ABIN1589633)

Antigène: FGF4 (Fibroblast Growth Factor 4 (FGF4))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: Escherichia coli (E. coli)

Pureté: > 95 % by SDS-PAGE

Détail du produit

Fonction: Recombinant Human FGF-4 Protein

Séquence: APTAPNGTLE AELERRWESL VALSLARLPV AAQPKEAAVQ SGAGDYLLGI KRLRRLYCNV GIGFHLQALP DGRIGGAHAD TRDSLLELSP VERGVVSIFG VASRFFVAMS SKGKLYGSPF FTDECTFKEI LLPNNYNAYE SYKYPGMFIA LSKNGKTKKG NRVSPTMKVT HFLP RL

Specificité: Chromosomal location:11q13.3

Attributs du produit: Length (aa):177

Information d'application

Indications d'application: The biological activity was determined by the induction of proliferation in NHDF cells (Normal Human Dermal Fibroblasts).

Commentaires:

Cytokines & Growth Factors

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: PBS (sterile),We recommend a quick spin followed by reconstitution in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers and stored at 4 °C for 1 week or -20 °C for future use.

Buffer: PBS

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles. We recommend a quick spin followed by reconstitution

Stock: 4 °C,-20 °C

Stockage commentaire: The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted FGF-4 should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles.

Date de péremption: 2-3 weeks

Détail du antigène

Antigène: FGF4 (Fibroblast Growth Factor 4 (FGF4))

Autre désignation: FGF-4

Sujet:

Synonyms: FGF4, HST, KFGF, HST-1, HSTF1, K-FGF, HBGF-4

Description: FGF-4 (fibroblast growth factor 4), also known as K-FGF (Kaposi's sarcoma associated FGF), is a 25 kDa secreted, heparin binding member of the FGF family. The human FGF-4 cDNA encodes 206 amino acids (aa) with a 33 aa signal sequence and a 173 aa mature protein with an FGF homology domain that contains a heparin binding region near the C terminus. Mature human FGF-4 shares a high aa identity with mouse, rat, canine and bovine FGF-4, respectively. The expression of FGF-4 and its receptors, FGF-R1c, -R2c, -R3c and R4, is spatially and temporally regulated during embryonic development. Its expression in the mouse trophoblast inner cell mass promotes expression of FGF-R2, and is required for maintenance of the trophectoderm and primitive endoderm. FGF-4 is proposed to play a physiologically relevant role in human embryonic stem cell self-renewal. It promotes stem cell proliferation, but may also aid differentiation depending on context and concentration, and is often included in embryonic stem cell media in-vitro. FGF-4 is mitogenic for fibroblasts and endothelial cells in-vitro and has autocrine transforming potential. It is a potent angiogenesis promoter in-vivo and has been investigated as therapy for coronary artery disease.

Poids moléculaire: 19.7 kDa

ID gène: 2249

NCBI Accession: NM_002007, NP_001998

UniProt: P08620

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance