HA2 Protein (His tag)

N° du produit ABIN1686739

Détail du produit

Antigène: HA2 (H(+)-ATPase 2 (HA2))

Type de proteíne: Recombinant

Origine: Souris

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette HA2 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS), Western Blotting (WB), Functional Studies (Func)

Séquence: MGHHHHHHMA KWGQGDPRWI VEEREDGTNV NNWHWTERDA TIWSKGKLRE LLVGIAMENE AGRCEISELK QVEGEASCNS RKGKLIFFYE WNIKLAWKGT VKESGAKHKG LIEIPSLSEE NEINDTEVNV SKKKGDGEIL KDLMRTTGTA KVREALGEYL KALKTEFTTG MILPTKAVAT QELTLQRKLN ENKLQASPVA LGVRIPTVAL HLTELFDTTV EQLYSIFTVK ELVQKFSKSP AVLEAERGGK FQMFDGNISG EYVELVTNRK IIMKWRCRNW PEEHYATVEL NFVPAPGQTE LQLDCKGVPV CKEENMKFCW QKQHFEEIKG LLELTAQNA

Specificité: ~38 kDa

Purification: Affinity Purified

Pureté: >90%

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

This product has been certified >90% pure using SDS - PAGE analysis.

Restrictions: For Research Use only

Stockage

Concentration: Lot specific

Buffer: 25 mM Trif buffer pH 7.2, 150 mM NaCl, 0.1 mM DTT, 50 % glycerol

Stock: -20 °C

Détail du antigène

Antigène: HA2 (H(+)-ATPase 2 (HA2))

Autre désignation: Aha2 (HA2 Produits)

Synonymes: AHA2 Protein, F9N11.40 Protein, F9N11_40 Protein, H(+)-ATPase 2 Protein, P-TYPE H(+)-ATPASE ISOFORM 2 Protein, PLASMA MEMBRANE PROTON ATPASE 2 Protein, PMA2 Protein, H[+]-ATPase 2 Protein, HA2 Protein

Sujet: Aha2 shares 45 % sequence homology with Aha1, however, little is known about the functional protein. Aha1 is a member of the HSP90 cochaperone family, and is thought to stimulate HSP90 ATPase activity by competing with p23 and other co-chaperones for HSP90 binding (1, 2). It may affect a step in the endoplasmic reticulum to Golgi trafficking. Aha1 also interacts with HSPCA/HSP90 and with the cytoplasmic tail of the vesicular stomatistis virus glycoproteins (VSV G) (3). Aha1 is expressed in numerous tissues, including the brain, heart, skeletal muscle, and kidney, and at low levels, the liver and placenta. Aha1 might be a potential therapeutic strategy to increase sensitivity to HSP inhibitors (4).

Poids moléculaire: approx. 38 kDa

ID gène: 268390

NCBI Accession: NM_172391

UniProt: Q8N9S3

Pathways: Cellular Glucan Metabolic Process, Proton Transport