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IL12 Protein (AA 23-219, AA 23-328)

IL12 Origine: Humain Hôte: HEK-293T Cells Recombinant > 95 % as analyzed by SDS-PAGE and HPLC. Active
N° du produit ABIN2018013
  • Antigène Voir toutes IL12 Protéines
    IL12 (Interleukin 12 (IL12))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    AA 23-219, AA 23-328
    Origine
    • 19
    • 11
    • 4
    • 1
    Humain
    Source
    • 14
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    HEK-293T Cells
    Attributs du produit
    EC50 < 2 ng/mL, measured by the induction of IFN-gamma from NK cells co-stimulated with IL-18, corresponding to a specific activity of > 1x10^6 units/mg.
    P35 subunit: AA 23-219 ,P40 subunit: AA 23-328
    Pureté
    > 95 % as analyzed by SDS-PAGE and HPLC.
    niveau d'endotoxine
    < 0.2 EU/μg, determined by LAL method.
    Top Product
    Discover our top product IL12 Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstituted in ddH2O or PBS at 100 μg/mL.
    Buffer
    Lyophilized after extensive dialysis against PBS.
    Stock
    -80 °C
    Stockage commentaire
    Lyophilized recombinant Human Interleukin 12(IL-12) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rh-IL12 should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
    Date de péremption
    6 months
  • Antigène
    IL12 (Interleukin 12 (IL12))
    Autre désignation
    Interleukin 12(IL-12) (IL12 Produits)
    Synonymes
    CLMF Protein, CLMF2 Protein, IL-12B Protein, NKSF Protein, NKSF2 Protein, p40 Protein, Il-12b Protein, Il12p40 Protein, Il-12p40 Protein, Il12 Protein, IL-12p40 Protein, IL-12 Protein, LOC100217488 Protein, IL-12p35 Protein, Il-12a Protein, Ll12a Protein, p35 Protein, IL12p40 Protein, IL12B Protein, IL-12 p35 Protein, interleukin 12B Protein, interleukin 12A Protein, interleukin 12b Protein, interleukin 12a Protein, Interleukin 12 level Protein, IL12B Protein, IL12A Protein, Il12b Protein, Il12a Protein, IL12 Protein, il12a Protein
    Sujet
    Interleukin 12 (IL-12), also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a pleiotropic cytokine originally identified in the medium of activated human B lymphoblastoid cell lines. The p40 subunit of IL-12 has been shown to have extensive amino acid sequence homology to the extracellular domain of the human IL-6 receptor while the p35 subunit shows distant but significant sequence similarity to IL-6, G-CSF, and chicken MGF. These observations have led to the suggestion that IL-12 might have evolved from a cytokine/soluble receptor complex. Human and mouse IL-12 share 70 % and 60 % amino acid sequence homology in their p40 and p35 subunits, respectively. IL-12 apparently shows species specificity with human IL-12 reportedly showing minimal activity in the mouse system.
    Synonyms: NKSF, CTL maturation factor (TCMF), Cytotoxic lymphocyte maturation factor (CLMF), TSF
    Poids moléculaire
    75 kDa, consisting of a 306 amino acid residue p40 subunit and a 197 amino acid residue p35 subunit.
    UniProt
    P29459, P29460
    Pathways
    Signalistation JAK/STAT, Signalisation TLR, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome
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