IL-6 Protein (AA 29-212)
Aperçu rapide pour IL-6 Protein (AA 29-212) (ABIN2018145)
Antigène
Voir toutes IL-6 (IL6) ProtéinesType de proteíne
Activité biologique
Origine
Source
Pureté
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Attributs du protein
- AA 29-212
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Attributs du produit
- ED50 < 0.06 ng/mL, measured in a cell proliferation assay using 7TD1 cells.
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niveau d'endotoxine
- < 0.2 EU/μg, determined by LAL method.
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Interleukin 6 (IL6) (AA 30-212) protein (His tag,mFc Tag)
IL6 Origine: Humain Hôte: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. IA, ADA, AM, ScA
Interleukin 6 (IL6) (AA 30-212) (Active) proteinIL6 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 95 % as determined by Bis-Tris PAGE,> 90 % as determined by HPLC Active
Interleukin 6 (IL6) (AA 28-212) (Active) protein (His tag)IL6 Origine: Cynomolgus Hôte: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Interleukin 6 (IL6) (AA 29-212) (Active) proteinIL6 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 95 % by SDS-PAGE analysis. Active
Interleukin 6 (IL6) (AA 25-211) (Active) protein (His tag)IL6 Origine: Souris Hôte: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE. Active
Interleukin 6 (IL6) (AA 30-212) (Active) protein (His tag)IL6 Origine: Humain Hôte: HEK-293 Cells > 97 % AcA, CC Active
Interleukin 6 (IL6) (AA 30-212) (Active) proteinIL6 Origine: Humain Hôte: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Interleukin 6 (IL6) (AA 1-212) protein (GST tag)IL6 Origine: Humain Hôte: Wheat germ Recombinant WB, ELISA, AA, AP
Interleukin 6 (IL6) (AA 30-212) (Active) protein (His tag)IL6 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 95 % SDS, AcA Active
Interleukin 6 (IL6) (AA 25-211) (Active) protein (His tag)IL6 Origine: Souris Hôte: Baculovirus infected Insect Cells Recombinant > 95 % SDS, AcA Active
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
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Buffer
- Lyophilized after extensive dialysis against PBS.
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Stock
- -80 °C
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Stockage commentaire
- Lyophilized recombinant Human Interleukin-6 remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Human Interleukin-6 should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
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Date de péremption
- 6 months
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- IL-6 (IL6) (Interleukin 6 (IL6))
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Autre désignation
- Interleukin-6 (IL-6)
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Sujet
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Interleukin-6 (IL-6), also known as BSF-2, CDF and IFNB2, is a pleiotropic cytokine that acts in both pro-inflammatory and anti-inflammatory responses. It is produced mainly by T cells, macrophages, monocytes, endothelial cells and muscle cells. IL-6 binds to IL-6 receptor (IL-6R) to trigger the association of IL-6R with gp130, inducing signal transduction through JAKs and STATs. The biological functions of IL-6 are diverse. It stimulates B cell differentiation and antibody production, myeloma and plasmacytoma growth, as well as nerve cell differentiation. It also acts as a myokine, produced by muscle cells in response to muscle contraction, to be released to the blood stream to help break down fats and improve insulin resistance.
Synonyms: 26 kDa protein, IFN-beta2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2 -
Poids moléculaire
- 21-23 kDa, observed by reducing SDS-PAGE.
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UniProt
- Q75MH2
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Pathways
- Signalisation TLR, Hormone Transport, Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Carbohydrate Metabolic Process, Autophagy, Cell RedoxHomeostasis, Cancer Immune Checkpoints, Inflammasome
Antigène
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