FKBP3 Protein (AA 1-224) (His tag)

N° du produit ABIN2115464

Détail du produit

Antigène: FKBP3 (FK506 Binding Protein 3, 25kDa (FKBP3))

Type de proteíne: Recombinant

Attributs du protein: AA 1-224

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette FKBP3 protéine est marqué à la His tag.

Fonction: Recombinant Human Peptidyl-Prolyl Cis-Trans Isomerase FKBP3 (N-6His)

Séquence: MGSSHHHHHH SSGLVPRGSH MAAAVPQRAW TVEQLRSEQL PKKDIIKFLQ EHGSDSFLAE HKLLGNIKNV AKTANKDHLV TAYNHLFETK RFKGTESISK VSEQVKNVKL NEDKPKETKS EETLDEGPPK YTKSVLKKGD KTNFPKKGDV VHCWYTGTLQ DGTVFDTNIQ TSAKKKKNAK PLSFKVGVGK VIRGWDEALL TMSKGEKARL EIEPEWAYGK KGQPDAKIPP NAKLTFEVEL VDID

Attributs du produit: Recombinant Human Peptidyl-prolyl cis-trans isomerase FKBP3 is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Asp224) of Human FKBP3/FKBP25 fused with a 6His tag at the N-terminus..

Pureté: > 95 % as determined by reducing SDS-PAGE.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl,1 mM DTT,10 % glycerol .

Agent conservateur: Dithiothreitol (DTT)

Précaution d'utilisation: This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Stock: -80 °C

Stockage commentaire: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Date de péremption: 6 months

Détail du antigène

Antigène: FKBP3 (FK506 Binding Protein 3, 25kDa (FKBP3))

Autre désignation: Peptidyl-Prolyl Cis-Trans Isomerase FKBP3 (FKBP3 Produits)

Synonymes: FKBP3 Protein, 25kDa Protein, FKBP-3 Protein, FKBP25 Protein, FK506 Protein, fb75c04 Protein, si:dz261o22.2 Protein, wu:fb75c04 Protein, zgc:110728 Protein, FKBP-25 Protein, PPIase Protein, FK506 binding protein 3 Protein, FK506 binding protein 3 L homeolog Protein, peptidylprolyl isomerase Protein, FKBP3 Protein, Fkbp3 Protein, fkbp3 Protein, fkbp3.L Protein, CAALFM_C103790CA Protein

Sujet: FKBP3 contains 1 PPIase FKBP-type domain, belongs to the FKBP-type PPIase family. FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. FKBP3 is a cis-trans prolyl isomerase enzyme that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.
Synonyms: Peptidyl-prolyl cis-trans isomerase FKBP3,PPIase FKBP3,25 kDa FK506-binding protein,25 kDa FKBP,FKBP-25,FK506-binding protein 3,FKBP-3,Immunophilin FKBP25,Rapamycin-selective 25 kDa immunophilin,Rotamase,FKBP25

Poids moléculaire: 27.3 kDa

UniProt: Q00688