IL-6 Protein (AA 30-212)

N° du produit ABIN2181322

Protéine Recombinant IL-6 exprimée dans HEK-293 Cells et a été mentionnée dans 4+ publications.

Aperçu rapide pour IL-6 Protein (AA 30-212) (ABIN2181322)

Antigène: IL-6 (IL6) (Interleukin 6 (IL6))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: HEK-293 Cells

Pureté: >90 % as determined by SDS-PAGE.

Détail du produit

Attributs du protein: AA 30-212

Marque: ActiveMax®

Séquence: AA 30-212

Attributs du produit: This protein carries no "tag". The protein has a calculated MW of 20.8 kDa. The protein migrates as 24-27 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4

Conseil sur la manipulation: Please avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).

Référence

Gao, Lu, Guo, Xin: "Dual-optofluidic waveguide in-line fiber biosensor for real-time label-free detection of interferon-gamma with temperature compensation." dans: Optics express, Vol. 28, Issue 7, pp. 10491-10504, (2021) (PubMed).

Lichtor, Chen, Elowe, Chen, Liu: "Side chain determinants of biopolymer function during selection and replication." dans: Nature chemical biology, Vol. 15, Issue 4, pp. 419-426, (2019) (PubMed).

Hao, Pan, Huang, Wang, Zhao: "Sensitive detection of lung cancer biomarkers using an aptameric graphene-based nanosensor with enhanced stability." dans: Biomedical microdevices, Vol. 21, Issue 3, pp. 65, (2019) (PubMed).

Hao, Pan, Shao, Lin, Zhao: "Graphene-based fully integrated portable nanosensing system for on-line detection of cytokine biomarkers in saliva." dans: Biosensors & bioelectronics, Vol. 134, pp. 16-23, (2019) (PubMed).

Détail du antigène

Antigène: IL-6 (IL6) (Interleukin 6 (IL6))

Autre désignation: IL-6

Sujet: Interleukin 6 (IL-6) is also known as HGF, BSF2,HSF, IFNB2 and IL-6, originally identified as a B cell differentiation factor, is a multifunctional cytokine that regulates immune responses, hematopoiesis, acute phase responses, and inflammatory reactions.It is secreted by T cells, macrophages , monocytes, fibroblasts,endothelial cells,et.al. to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. Interleukin 6 has been shown to interact with interleukin-6 receptor and glycoprotein. IL-6 is relevant to many disease processes such as diabetes,atherosclerosis, depression,Alzheimer's Disease,systemic,lupus erythematosus,prostate cancer and rheumatoid arthritis. Advanced/metastatic cancer patients have higher levels of IL-6 in their blood.Hence there is an interest in developing anti-IL-6 agents as therapy against many of these diseases.

Poids moléculaire: 20.8 kDa

NCBI Accession: NP_000591

Pathways: Signalisation TLR, Hormone Transport, Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Carbohydrate Metabolic Process, Autophagy, Cell RedoxHomeostasis, Cancer Immune Checkpoints, Inflammasome