CLEC4G Protein (AA 55-293) (Fc Tag)

N° du produit ABIN2444087

Détail du produit

Antigène: CLEC4G (C-Type Lectin Domain Family 4, Member G (CLEC4G))

Type de proteíne: Recombinant

Attributs du protein: AA 55-293

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette CLEC4G protéine est marqué à la Fc Tag.

Séquence: AA 55-293

Attributs du produit: This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 52.1 kDa. The protein migrates as 65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Pureté: >85 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 50 mM Tris, 100 mM Glycine, pH 7.5

Conseil sur la manipulation: Please avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: Lyophilized Protein should be stored at -20 °C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20 °C or -71 °C. Avoid repeated freeze-thaw cycles.

Référence

Yu, Huang, Chen, Liu, Wu, Pu, Wang, Kang, Zhou: "Characterization of a novel anti-human lymphocyte activation gene 3 (LAG-3) antibody for cancer immunotherapy." dans: mAbs, Vol. 11, Issue 6, pp. 1139-1148, (2019) (PubMed).

Détail du antigène

Antigène: CLEC4G (C-Type Lectin Domain Family 4, Member G (CLEC4G))

Autre désignation: LSECtin (CLEC4G Produits)

Synonymes: RGD1562320 Protein, DTTR431 Protein, LP2698 Protein, LSECtin Protein, UNQ431 Protein, 4930572L20Rik Protein, C-type lectin domain family 4 member G Protein, C-type lectin domain family 4, member G Protein, C-type lectin domain family 4, member g Protein, CLEC4G Protein, Clec4g Protein

Sujet: C-type lectin superfamily 4, member G (CLEC4G) is also known as liver and lymph node sinusoidal endothelial cell C-type lectin (LSECtin), which is a member of subgroup II of the C-type (Ca2+-dependent) lectin superfamily. CLEC4G / LSECtin binds to mannose, GlcNAc, and fucose in a Ca2+-dependent manner. In addition, CLEC4G / LSECtin has the ability to bind to surface glycoproteins of enveloped viruses. In particular, interaction of LSECtin with the surface glycoproteins of severe acute respiratory syndrome (SARS) coronavirus and Ebola virus has been described, and LSECtin-mediated infection of cells by Ebola virus has been demonstrated.

Poids moléculaire: 52.1 kDa

NCBI Accession: NP_940894

UniProt: Q6UXB4