ATG7 Protein (AA 450-698) (His tag)

N° du produit ABIN2468252

Détail du produit

Antigène: ATG7 (ATG7 Autophagy Related 7 (ATG7))

Type de proteíne: Recombinant

Attributs du protein: AA 450-698

Origine: Souris

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette ATG7 protéine est marqué à la His tag.

Application: Western Blotting (WB), ELISA, Mass Spectrometry (MS), Neutralization (Neut)

Pureté: ~95 %

Information d'application

Indications d'application: This recombinant protein can be used for WB, ELISA, MS and neutralization assays.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 1X PBS containing 10 % glycerol

Conseil sur la manipulation: Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Stock: -80 °C

Stockage commentaire: Store in working aliquots at -70 °C.

Détail du antigène

Antigène: ATG7 (ATG7 Autophagy Related 7 (ATG7))

Autre désignation: ATG7 (ATG7 Produits)

Synonymes: APG7-LIKE Protein, APG7L Protein, GSA7 Protein, D8 Protein, UBA1B Protein, UBE1L Protein, UBE2 Protein, Ube1l Protein, 1300004C08Rik Protein, AO090001000744 Protein, atg7 Protein, 1810013K23Rik Protein, Agp7 Protein, Apg7l Protein, Atg7l Protein, ATAPG7 Protein, ATATG7 Protein, ATG7 Protein, AUTOPHAGY 7 Protein, AUTOPHAGY-RELATED 7 Protein, K15I22.10 Protein, K15I22_10 Protein, autophagy related 7 Protein, ubiquitin like modifier activating enzyme 7 Protein, ubiquitin-like modifier activating enzyme 7 Protein, autophagy-related protein 7 Protein, Autophagy-related protein 7 Protein, Apg7p Protein, ThiF family protein Protein, ubiquitin-like conjugating enzyme Atg7 Protein, ATG7 Protein, UBA7 Protein, Uba7 Protein, ANI_1_3368024 Protein, AOR_1_1338164 Protein, PTRG_02236 Protein, PAAG_00287 Protein, PITG_12537 Protein, atg7 Protein, Atg7 Protein, APG7 Protein

Sujet: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2). This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1 (3). Another member of the autophagy family of proteins is APG7 which was identified in yeast as a ubiquitin-E1-like enzyme , this function is conserved in the mammalian homolog (4). In mammalian cells, APG7 is essential for autophagy conjugation systems, autophagosome formation, starvation-induced bulk degradation of proteins and organelles (5). It has been suggested that caspase-8 may alter APG7 levels and thus the APG7 program of autophagic cell death (6).

Poids moléculaire: 30 kDa (Calculated)

ID gène: 74244

OMIM: 37589293

UniProt: Q9D906

Pathways: Response to Water Deprivation, Autophagy