Calreticulin Protein (CALR) (AA 18-417)

N° du produit ABIN2468306

Cette protéine Recombinant Calreticulin est produite dans Escherichia coli (E. coli).

Aperçu rapide pour Calreticulin Protein (CALR) (AA 18-417) (ABIN2468306)

Antigène: Calreticulin (CALR)

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Application: Western Blotting (WB), ELISA, Mass Spectrometry (MS)

Pureté: ~90 %

Détail du produit

Attributs du protein: AA 18-417

Information d'application

Indications d'application: This recombinant protein can be used for WB, ELISA, MS.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM Tris, pH 8.0, 0.002 % NaN, 3 mM NaCl, 2.5 mM

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Stock: -80 °C

Stockage commentaire: Store in working aliquots at -70 °C.

Détail du antigène

Antigène: Calreticulin (CALR)

Autre désignation: CALR

Sujet: Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium.

Poids moléculaire: 46 kDa (Calculated)

ID gène: 811

NCBI Accession: NP_004334

OMIM: 4757900

UniProt: P27797

Pathways: Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, ER-Nucleus Signaling, Unfolded Protein Response