ITGA4 Protein (AA 131-275) (His tag)

N° du produit ABIN2468725

Détail du produit

Antigène: ITGA4 (Integrin alpha 4 (ITGA4))

Type de proteíne: Recombinant

Attributs du protein: AA 131-275

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette ITGA4 protéine est marqué à la His tag.

Application: Western Blotting (WB), ELISA, Mass Spectrometry (MS), Neutralization (Neut)

Pureté: ~95 %

Information d'application

Indications d'application: This recombinant protein can be used for WB, ELISA, MS and neutralization assays.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 50 mM Tris pH 7.5, 150 mM NaCl, 5 mM MgCl2

Conseil sur la manipulation: Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Stock: -80 °C

Stockage commentaire: Store in working aliquots at -70 °C.

Détail du antigène

Antigène: ITGA4 (Integrin alpha 4 (ITGA4))

Autre désignation: Integrin alpha 4 (ITGA4 Produits)

Synonymes: CD49D Protein, IA4 Protein, LOC100219853 Protein, integrin subunit alpha 4 Protein, integrin alpha 4 Protein, integrin subunit alpha 4 S homeolog Protein, ITGA4 Protein, Itga4 Protein, itga4.S Protein

Sujet: The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains (reviewed in 1). Alpha 4 (?4) chain associates with either beta 1 (?1) or beta 7???7) chain. It has been demonstrated that the putative ligand-binding sites of both integrin ?4?1 and ?4?7 is located on the ?4 chain. These ligands included Madcam, VCAM, and fibronectin (2-4). Madcam is known as the principal ligand for integrin a4b7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin ?4?7, the gut mucosal homing receptor for peripheral T cells (5). This recombinant protein fragment includes the ligand and monoclonal antibody binding domains , this binding has been tested and verified in ELISA assays. This recombinant protein is recognized PSI antibodies Integrin 4? (IN1) (PSI 4827) and Integrin 4? (IN2) (PSI 4837), but not Integrin 4? (CT) (PSI 4783).

Poids moléculaire: 17 kDa (Calculated)

ID gène: 3676

NCBI Accession: NP_000876

OMIM: 67191027

UniProt: P13612

Pathways: Integrin Complex