RCAN2 Protein (AA 2-197, Isoform 2) (His tag)

N° du produit ABIN2469007

Détail du produit

Antigène: RCAN2 (Regulator of Calcineurin 2 (RCAN2))

Type de proteíne: Recombinant

Attributs du protein: Isoform 2, AA 2-197

Origine: Souris

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette RCAN2 protéine est marqué à la His tag.

Application: ELISA, Western Blotting (WB), Mass Spectrometry (MS), Neutralization (Neut)

Pureté: ~95 %

Information d'application

Indications d'application: This recombinant protein can be used for WB, ELISA, MS and neutralization assays.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 100 mM sodium phosphate, 10 mM Tris, 500 mM NaCl, 25 mM imidazole, 2 mM MgCl2, 10 % gycerol

Conseil sur la manipulation: Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Stock: -80 °C

Stockage commentaire: Store in working aliquots at -70 °C.

Détail du antigène

Antigène: RCAN2 (Regulator of Calcineurin 2 (RCAN2))

Autre désignation: RCAN2 (RCAN2 Produits)

Synonymes: DSCR1L1 Protein, si:ch211-124g24.1 Protein, zgc:85746 Protein, RCAN2 Protein, DKFZp459H071 Protein, rcan2 Protein, CSP2 Protein, MCIP2 Protein, RCN2 Protein, ZAKI-4 Protein, ZAKI4 Protein, Csp2 Protein, Dscr1l1 Protein, Dcip2 Protein, Zaki-4 Protein, regulator of calcineurin 2 Protein, rcan2 Protein, RCAN2 Protein, Rcan2 Protein

Sujet: Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle (1,2). Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin s activity (3). Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3 (3). RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome (4).

Poids moléculaire: 26 kDa (Calculated)

ID gène: 53901

OMIM: 38328420

UniProt: Q9JHG2