ACVR2B Protein (His tag)
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- Antigène Voir toutes ACVR2B Protéines
- ACVR2B (Activin A Receptor, Type IIB (ACVR2B))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette ACVR2B protéine est marqué à la His tag.
- Application
- Western Blotting (WB)
- Attributs du produit
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Measured by its ability to inhibit Activin Ainduced hemoglobin expression in K562 human chronic myelogenous leukemia cells. Approximately 0. 2-0. 5 μg/mL of recombinant human ActivinR-IIB will inhibit 50 % of the biological response due to 3 ng/mL of rhActivin A.
Fusion tag: C-His Tag
- Pureté
- >97 % as determined by SDS-PAGE.
- Top Product
- Discover our top product ACVR2B Protéine
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- Indications d'application
- This recombinant protein can be used for WB. For research use only.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Stock
- -80 °C,-20 °C
- Stockage commentaire
- Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
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- Antigène
- ACVR2B (Activin A Receptor, Type IIB (ACVR2B))
- Autre désignation
- ACVR2B (ACVR2B Produits)
- Synonymes
- ACVR2B Protein, XAR1 Protein, actr-iib Protein, actriib Protein, ACTRIIB Protein, ActR-IIB Protein, HTX4 Protein, ActRIIB Protein, actr2b Protein, actrIIb Protein, wu:fj97d11 Protein, activin A receptor type 2B Protein, activin A receptor type 2B L homeolog Protein, activin A receptor type 2Ba Protein, activin receptor IIB Protein, ACVR2B Protein, acvr2b Protein, acvr2b.L Protein, Acvr2b Protein, acvr2ba Protein
- Sujet
- Activin receptor type-2B (ACVR2B) is also known as ActR-IIB and MGC116908, ACVR2B is an activin type 2 receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. Defects in ACVR2B are the cause of visceral heterotaxy autosomal type 4 (HTX4).
- Poids moléculaire
- 14.5 kDa
- ID gène
- 93
- NCBI Accession
- NP_001097
- UniProt
- Q13705
- Pathways
- Hormone Transport, Cancer Immune Checkpoints
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