CSF3R Protein (His tag)

N° du produit ABIN2566610

Détail du produit

Antigène: CSF3R (Colony Stimulating Factor 3 Receptor (Granulocyte) (CSF3R))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette CSF3R protéine est marqué à la His tag.

Application: Western Blotting (WB)

Attributs du produit:

Measured by its ability to inhibit the GCSF-induced proliferation of NFS-60 mouse myeloid cells. The ED50 for this effect is typically 0. 02-2 μg /mL in the presence of 0. 125 ng /mL of recombinant human GCSF.

Fusion tag: C-His Tag

Pureté: >95 % as determined by SDS-PAGE.

Information d'application

Indications d'application: This recombinant protein can be used for WB. For research use only.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4

Stock: -80 °C,-20 °C

Stockage commentaire: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.

Détail du antigène

Antigène: CSF3R (Colony Stimulating Factor 3 Receptor (Granulocyte) (CSF3R))

Autre désignation: GCSFR (CSF3R Produits)

Synonymes: CD114 Protein, GCSFR Protein, Cd114 Protein, Csfgr Protein, G-CSF-R Protein, G-CSFR Protein, CSF3R Protein, gcsfr Protein, cd114 Protein, colony stimulating factor 3 receptor Protein, colony stimulating factor 3 receptor (granulocyte) Protein, colony stimulating factor 3 receptor L homeolog Protein, granulocyte colony-stimulating factor receptor Protein, CSF3R Protein, Csf3r Protein, csf3r Protein, csf3r.L Protein, LOC100433338 Protein

Sujet: Granulocyte Colony Stimulating Factor Receptor (G-CSFR) is also known as Cluster of Differentiation 114 (CD114), CSF3R and GCSF, is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF), a cytokine that plays a critical role in the regulation of the activation, proliferation, differentiation, and survival of the neutrophilic granulocyte lineage. G-CSFR belongs to a family of cytokine receptors known as the hematopoietin receptor family. This type I membrane protein has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin type I II (FNIII) domains in the extracellular region. G-CSFR is present mainly on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages. G-CSFR mediates the specific effect of GCSF through activating a variety of intracellular signaling cascades, including the Jak/Stat, PI3/Akt, Ras-Raf-MAP kinase, and Src family kinase pathways, and thus functions in defense against infection, inflammation and repair, and in the maintenance of steady state hematopoiesis. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. Mutations in the intracellular part of this receptor are also associated with certain types of leukemia.

Poids moléculaire: 69 kDa

ID gène: 1441

NCBI Accession: NP_000751

UniProt: Q99062