Osteoactivin Protein (GPNMB) (His tag)
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- Antigène Voir toutes Osteoactivin (GPNMB) Protéines
- Osteoactivin (GPNMB)
- Type de proteíne
- Recombinant
- Activité biologique
- Active
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette Osteoactivin protéine est marqué à la His tag.
- Application
- Western Blotting (WB)
- Attributs du produit
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Measured by the ability of the immobilized protein to induce pro-MMP-9 secretion by NHLF human normal lung fibroblasts. The ED50 for this effect is typically 4 - 16 μg/mL.
- Pureté
- >95 % as determined by SDS-PAGE.
- Top Product
- Discover our top product GPNMB Protéine
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- Indications d'application
- This recombinant protein can be used for WB. For research use only.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Stock
- -80 °C,-20 °C
- Stockage commentaire
- Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
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- Antigène
- Osteoactivin (GPNMB)
- Autre désignation
- Osteoactivin (GPNMB Produits)
- Synonymes
- HGFIN Protein, NMB Protein, DC-HIL Protein, Dchil Protein, ipd Protein, glycoprotein nmb Protein, glycoprotein (transmembrane) nmb Protein, glycoprotein nmb L homeolog Protein, Gpnmb Protein, GPNMB Protein, gpnmb.L Protein
- Sujet
- Transmembrane glycoprotein NMB (GPNMB) is also known as Transmembrane glycoprotein HGFIN, DC-HIL and Osteoactivin (OA), which belongs to the PMEL/NMB family. GPNMB contains one PKD domain. GPNMB is a transmembrane glycoprotein that is up-regulated in various cancer cells, including in glioblastoma multiforme and is expressed in many melanoma cells, as well as in tissue macrophages. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages.
- Poids moléculaire
- 52.9 kDa
- ID gène
- 10457
- UniProt
- Q14956
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