APEX2 Protein (Myc-DYKDDDDK Tag)

N° du produit ABIN2714790

Détail du produit

Antigène: APEX2 (APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette APEX2 protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human APEX2 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: APEX2 (APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2))

Autre désignation: Apex2 (APEX2 Produits)

Synonymes: APE2 Protein, APEXL2 Protein, XTH2 Protein, ape2 Protein, apexl2 Protein, xth2 Protein, zgc:55889 Protein, C430040P13Rik Protein, apurinic/apyrimidinic endodeoxyribonuclease 2 Protein, APEX nuclease (apurinic/apyrimidinic endonuclease) 2 Protein, apurinic/apyrimidinic endodeoxyribonuclease 2 L homeolog Protein, apurinic/apyrimidinic endonuclease 2 Protein, APEX2 Protein, apex2 Protein, apex2.L Protein, Apex2 Protein

Sujet: Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Poids moléculaire: 57.2 kDa

NCBI Accession: NP_055296