Ataxin 1 Protein (ATXN1) (Transcript Variant 2) (Myc-DYKDDDDK Tag)

N° du produit ABIN2715013

Détail du produit

Antigène: Ataxin 1 (ATXN1)

Type de proteíne: Recombinant

Attributs du protein: Transcript Variant 2

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette Ataxin 1 protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human Ataxin-1 (transcript variant 2) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: Ataxin 1 (ATXN1)

Autre désignation: Ataxin-1 (ATXN1 Produits)

Synonymes: ATX1 Protein, D6S504E Protein, SCA1 Protein, ATXN1 Protein, ataxin 1b Protein, atxn1 Protein, 2900016G23Rik Protein, Atx1 Protein, C85907 Protein, ENSMUSG00000074917 Protein, Gm10786 Protein, Sca1 Protein, CG4547 Protein, Dmel\\CG4547 Protein, dAtx-1 Protein, dAtx1 Protein, sca1 Protein, ataxin 1 Protein, ataxin 1b Protein, Ataxin 1 Protein, ATXN1 Protein, atxn1b Protein, Atxn1 Protein, Atx-1 Protein

Sujet: The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 40-83 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene.

Poids moléculaire: 86.7 kDa

NCBI Accession: NP_001121636

Pathways: Synaptic Membrane