AUH Protein (Myc-DYKDDDDK Tag)

N° du produit ABIN2715079

Détail du produit

Antigène: AUH (AU RNA Binding Protein/enoyl-CoA Hydratase (AUH))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette AUH protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human AUH protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: AUH (AU RNA Binding Protein/enoyl-CoA Hydratase (AUH))

Autre désignation: Auh (AUH Produits)

Synonymes: C77140 Protein, W91705 Protein, wu:fb81b10 Protein, zgc:101057 Protein, AU RNA binding methylglutaconyl-CoA hydratase Protein, AU RNA binding protein/enoyl-coenzyme A hydratase Protein, AU RNA binding protein/enoyl-CoA hydratase Protein, AU RNA binding protein/enoyl-CoA hydratase S homeolog Protein, AUH Protein, Auh Protein, auh Protein, auh.S Protein

Sujet: This gene encodes bifunctional mitochondrial protein that has both RNA-binding and hydratase activities. The encoded protein is a methylglutaconyl-CoA hydratase that catalyzes the hydration of 3-methylglutaconyl-CoA to 3-hydroxy-3-methyl-glutaryl-CoA, a critical step in the leucine degradation pathway. This protein also binds AU-rich elements (AREs) found in the 3' UTRs of rapidly decaying mRNAs including c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. This protein is localizes to the mitochondrial matrix and the inner mitochondrial membrane and may be involved in mitochondrial protein synthesis. Mutations in this gene are the cause of 3-methylglutaconic aciduria, type I. Alternative splicing results in multiple transcript variants.

Poids moléculaire: 29.1 kDa

NCBI Accession: NP_001689