BAP1 Protein (Myc-DYKDDDDK Tag)

N° du produit ABIN2715149

Détail du produit

Antigène: BAP1 (BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette BAP1 protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human BAP1 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: BAP1 (BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1))

Autre désignation: Bap1 (BAP1 Produits)

Synonymes: HUCEP-13 Protein, UCHL2 Protein, BAIAP3 Protein, 2300006C11Rik Protein, AA989761 Protein, AW553466 Protein, mKIAA0272 Protein, uch-x4 Protein, hucep-13 Protein, hucep-6 Protein, uchl2 Protein, si:dkey-42i9.9 Protein, BRCA1 associated protein 1 Protein, Brca1 associated protein 1 Protein, BRCA1 associated protein 1 L homeolog Protein, BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) Protein, BAP1 Protein, Bap1 Protein, bap1.L Protein, bap1 Protein

Sujet: This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma.

Poids moléculaire: 80.2 kDa

NCBI Accession: NP_004647