BCR Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)
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- Antigène Voir toutes BCR Protéines
- BCR (Breakpoint Cluster Region (BCR))
- Type de proteíne
- Recombinant
- Attributs du protein
- Transcript Variant 2
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette BCR protéine est marqué à la Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Attributs du produit
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- Recombinant human BCR (transcript variant 2) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Pureté
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product BCR Protéine
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- Indications d'application
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Commentaires
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Stock
- -80 °C
- Stockage commentaire
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Antigène
- BCR (Breakpoint Cluster Region (BCR))
- Autre désignation
- Bcr (BCR Produits)
- Synonymes
- si:dkey-83d9.7 Protein, zK83D9.7 Protein, BCR Protein, ALL Protein, BCR1 Protein, CML Protein, D22S11 Protein, D22S662 Protein, PHL Protein, 5133400C09Rik Protein, AI561783 Protein, AI853148 Protein, mKIAA3017 Protein, breakpoint cluster region Protein, BCR, RhoGEF and GTPase activating protein Protein, bcr Protein, BCR Protein, Bcr Protein
- Sujet
- A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
- Poids moléculaire
- 137.5 kDa
- NCBI Accession
- NP_067585
- Pathways
- Regulation of Leukocyte Mediated Immunity, Platelet-derived growth Factor Receptor Signaling
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