Rubicon Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)

N° du produit ABIN2724189

Détail du produit

Antigène: Rubicon (KIAA0226) (KIAA0226)

Type de proteíne: Recombinant

Attributs du protein: Transcript Variant 2

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette Rubicon protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human KIAA0226 (transcript variant 2) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: Rubicon (KIAA0226) (KIAA0226)

Autre désignation: Kiaa0226 (KIAA0226 Produits)

Synonymes: RUBICON Protein, 5330403K09 Protein, Kiaa0226 Protein, Rubicon Protein, mKIAA0226 Protein, RUN and cysteine rich domain containing beclin 1 interacting protein Protein, KIAA0226 Protein, RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein Protein, RUBCN Protein, KIAA0226 Protein, Rubcn Protein

Sujet: The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Poids moléculaire: 108.4 kDa

NCBI Accession: NP_055502

Pathways: Autophagy