PDHX Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

N° du produit ABIN2728549

Détail du produit

Antigène: PDHX (Pyruvate Dehydrogenase Complex, Component X (PDHX))

Type de proteíne: Recombinant

Attributs du protein: Transcript Variant 1

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette PDHX protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human PDHX / PDX1 (transcript variant 1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: PDHX (Pyruvate Dehydrogenase Complex, Component X (PDHX))

Autre désignation: Pdhx,pdx1 (PDHX Produits)

Synonymes: DLDBP Protein, E3BP Protein, OPDX Protein, PDX1 Protein, proX Protein, AI481367 Protein, E3bp Protein, Pdx1 Protein, Ac1164 Protein, zgc:66110 Protein, zgc:85977 Protein, MGC86218 Protein, PDHX Protein, DDBDRAFT_0168431 Protein, DDBDRAFT_0230192 Protein, DDB_0168431 Protein, DDB_0230192 Protein, pyruvate dehydrogenase complex component X Protein, pyruvate dehydrogenase complex, component X Protein, pyruvate dehydrogenase complex component X L homeolog Protein, E3-binding protein Protein, PDHX Protein, Pdhx Protein, pdhx Protein, pdhx.L Protein, pdhX Protein

Sujet: The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. The PDH complex thereby links glycolysis to Krebs cycle. The PDH complex contains three catalytic subunits, E1, E2, and E3, two regulatory subunits, E1 kinase and E1 phosphatase, and a non-catalytic subunit, E3 binding protein (E3BP). This gene encodes the E3 binding protein subunit also known as component X of the pyruvate dehydrogenase complex. This protein tethers E3 dimers to the E2 core of the PDH complex. Defects in this gene are a cause of pyruvate dehydrogenase deficiency which results in neurological dysfunction and lactic acidosis in infancy and early childhood. This protein is also a minor antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95 % of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to cirrhosis and liver failure. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009].

Poids moléculaire: 53.9 kDa

NCBI Accession: NP_003468