Vinculin Protein (VCL) (Transcript Variant 2) (Myc-DYKDDDDK Tag)

N° du produit ABIN2735299

Détail du produit

Antigène: Vinculin (VCL)

Type de proteíne: Recombinant

Attributs du protein: Transcript Variant 2

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette Vinculin protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human Vinculin (VCL) (transcript variant 2) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Référence

Beppu, Sawai, Satoh, Mori, Kazami, Misawa, Shibuya, Ishibashi, Sogawa, Kado, Kodera, Nomura, Kuwabara: "Autoantibodies against vinculin in patients with chronic inflammatory demyelinating polyneuropathy." dans: Journal of neuroimmunology, Vol. 287, pp. 9-15, (2015) (PubMed).

Détail du antigène

Antigène: Vinculin (VCL)

Abstract: VCL Produits

Synonymes: CMD1W Protein, CMH15 Protein, MV Protein, MVCL Protein, VCL Protein, im:6902790 Protein, hm:zehn2160 Protein, DDBDRAFT_0186762 Protein, DDBDRAFT_0232320 Protein, DDB_0186762 Protein, DDB_0232320 Protein, 9430097D22 Protein, AA571387 Protein, AI462105 Protein, AW545629 Protein, CG3299 Protein, CT11081 Protein, Dmel\\CG3299 Protein, Dmvincp Protein, EG:103B4.1 Protein, Vin Protein, Vin2EF Protein, vinc Protein, LOC100228062 Protein, vcl-A Protein, vinculin Protein, vinculin a Protein, vinculin A Protein, Vinculin Protein, vinculin S homeolog Protein, VCL Protein, vcla Protein, vinA Protein, Vcl Protein, Vinc Protein, CpipJ_CPIJ013873 Protein, Bm1_37935 Protein, vcl Protein, vcl.S Protein

Sujet: Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.

Poids moléculaire: 116.5 kDa

NCBI Accession: NP_003364

Pathways: Cell-Cell Junction Organization, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2