WRAP53 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)

N° du produit ABIN2735538

Détail du produit

Antigène: WRAP53 (WD Repeat Containing, Antisense To TP53 (WRAP53))

Type de proteíne: Recombinant

Attributs du protein: Transcript Variant 2

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette WRAP53 protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human WDR79 / TCAB1 (transcript variant 2) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: WRAP53 (WD Repeat Containing, Antisense To TP53 (WRAP53))

Autre désignation: Wdr79,tcab1 (WRAP53 Produits)

Synonymes: DKCB3 Protein, TCAB1 Protein, WDR79 Protein, Wdr79 Protein, BC021790 Protein, WD repeat containing antisense to TP53 Protein, WD repeat containing, antisense to TP53 Protein, WD repeat containing, antisense to Trp53 Protein, WRAP53 Protein, Wrap53 Protein

Sujet: This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene.

Poids moléculaire: 59.1 kDa

NCBI Accession: NP_001137462

Pathways: Telomere Maintenance