Transferrin Receptor 2 Protein (TFR2) (AA 103-798) (Fc Tag)

N° du produit ABIN4949192

Cette protéine Recombinant Transferrin Receptor 2 est produite dans HEK-293 Cells. Il y a 1 publication disponible.

Aperçu rapide pour Transferrin Receptor 2 Protein (TFR2) (AA 103-798) (Fc Tag) (ABIN4949192)

Antigène: Transferrin Receptor 2 (TFR2)

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Application: Functional Studies (Func)

Pureté: >95 % as determined by SDS-PAGE.

Détail du produit

Attributs du protein: AA 103-798

Purification/Conjugué: Cette Transferrin Receptor 2 protéine est marqué à la Fc Tag.

Séquence: AA 103-798

Attributs du produit: This protein carries a mouse IgG1 Fc tag at the N-terminus, and has a calculated MW of 103.2 kDa. The predicted N-terminus is Ile. The reducing (R) protein migrates as 116 kDa in SDS-PAGE due to glycosylation.

niveau d'endotoxine: Less than 0.1 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Tris with Glycine, Arginine and NaCl,  pH 7.5

Conseil sur la manipulation: Please avoid repeated freeze-thaw cycles.

Stock: -20 °C

Référence

Stocki, Szary, Rasmussen, Demydchuk, Northall, Logan, Gauhar, Thei, Moos, Walsh, Rutkowski: "Blood-brain barrier transport using a high affinity, brain-selective VNAR antibody targeting transferrin receptor 1." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 35, Issue 2, pp. e21172, (2021) (PubMed).

Détail du antigène

Antigène: Transferrin Receptor 2 (TFR2)

Autre désignation: Transferrin R2

Sujet: Transferrin receptor protein 2 (TFR2) is a single-pass type II membrane protein with a protease associated (PA) domain, an M28 peptidase domain and a transferrin receptor-like dimerization domain. The mutations in TFR2 gene have been associated with hereditary hemochromatosis type III. Furthermore, TFR2 is involved in the uptake of transferrin-bound iron into cells by endocytosis, although its role is minor compared to transferrin receptor 1.

Poids moléculaire: 101.1 kDa

NCBI Accession: NP_056614

UniProt: Q9JKX3

Pathways: Transition Metal Ion Homeostasis