PTPRD
(Protein tyrosine Phosphatase, Receptor Type, D (PTPRD))
Type de proteíne
Recombinant
Attributs du protein
AA 21-1265
Origine
Humain
Source
HEK-293 Cells
Purification/Conjugué
Cette PTPRD protéine est marqué à la His tag.
Séquence
AA 21-1265
Attributs du produit
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 140 kDa. The protein migrates as 19 kDa and 120-130 kDa under reducing (R) condition (SDS-PAGE).
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Sujet
Receptor-type tyrosine-protein phosphatase delta is an enzyme that is encoded by the PTPRD gene. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPRD has been shown to interact with PTPRS and liprin-alpha-1. Studies of the similar genes in chick and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple tissue specific alternatively spliced transcript variants of this gene have been reported. Mutations in the PTPRD gene are associated with autism, obsessive-compulsive disorder, and breast cancer.