CRTAM Protein (partial) (Fc Tag)

N° du produit ABIN5608367

Détail du produit

Antigène: CRTAM (Cytotoxic and Regulatory T Cell Molecule (CRTAM))

Type de proteíne: Recombinant

Attributs du protein: partial

Origine: Cynomolgus

Source: HEK-293 Cells

Purification/Conjugué: Cette CRTAM protéine est marqué à la Fc Tag.

Application: Western Blotting (WB)

Séquence: Ser 18 - Gly 287

Pureté: >90 % as determined by SDS-PAGE.

niveau d'endotoxine: Endotoxin level is less than 1.0 EU per ug by the LAL method.

Information d'application

Indications d'application: This recombinant protein can be used for WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 50 mM Tris, 100 mM Glycine, pH 7.5

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C,-80 °C

Stockage commentaire: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C.

Détail du antigène

Antigène: CRTAM (Cytotoxic and Regulatory T Cell Molecule (CRTAM))

Autre désignation: CRTAM (CRTAM Produits)

Synonymes: TAD Protein, cTADS Protein, MGC82176 Protein, CRTAM Protein, CD355 Protein, cytotoxic and regulatory T-cell molecule Protein, cytotoxic and regulatory T-cell molecule L homeolog Protein, cytotoxic and regulatory T cell molecule Protein, CRTAM Protein, crtam.L Protein, Crtam Protein

Sujet: Class I-restricted T cell-associated molecule (CRTAM), a member of nectin family and the immunoglobulin superfamily, is also known as cytotoxic and regulatory T-cell molecule, which is expressed by activated CD8+ and NK T cells. CRTAM is found in spleen, thymus, small intestine, peripheral blood, and surprisingly, in brain where it is highly expressed by Purkinje cells of the cerebellum. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions (3 - 5). IGSF4 and T cell receptor co-engagement of CRTAM-expressing CD8+ cells induces increased IFN-gamma or IL-22 production (3, 4). Furthermore, a role in cancer surveillance through NK cell-mediated rejection of IGSF4-expressing tumors has been proposed.

Poids moléculaire: 56.6 kDa

ID gène: 102125896

NCBI Accession: XP_005580021

UniProt: G7PPC7

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation