nectin-3 Protein (partial) (Fc Tag)
-
- Antigène Voir toutes nectin-3 (NECTIN3) Protéines
- nectin-3 (NECTIN3) (Nectin cell adhesion molecule 3 (NECTIN3))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- partial
-
Origine
- Humain
-
Source
- HEK-293 Cells
- Purification/Conjugué
- Cette nectin-3 protéine est marqué à la Fc Tag.
- Application
- Western Blotting (WB), ELISA
- Séquence
- Gly 58 - Asp 400
- Pureté
- >95 % as determined by SDS-PAGE.
- niveau d'endotoxine
- Endotoxin level is less than 1.0 EU per ug by the LAL method.
- Biological Activity Comment
-
Measured by its binding ability in a functional ELISA. Immobilized Human CD113, Fc Tag at 10 μg/mL (100 uL/well) can bind Biotinylated Human TIGIT, His Tag with a linear range of 0.3-5 μg/mL (QC tested).
- Top Product
- Discover our top product NECTIN3 Protéine
-
-
- Indications d'application
- This recombinant protein can be used for E, WB.
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Buffer
- 50 mM Tris, 100 mM Glycine, pH 7.5
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C.
-
- Antigène
- nectin-3 (NECTIN3) (Nectin cell adhesion molecule 3 (NECTIN3))
- Autre désignation
- Nectin-3 (NECTIN3 Produits)
- Synonymes
- PVRL3 Protein, CD113 Protein, CDW113 Protein, NECTIN-3 Protein, PPR3 Protein, PRR3 Protein, PVRR3 Protein, 2610301B19Rik Protein, 3000002N23Rik Protein, 4921513D19Rik Protein, AA407785 Protein, AU016832 Protein, AW538082 Protein, nectin cell adhesion molecule 3 Protein, poliovirus receptor-related 3 Protein, Nectin3 Protein, NECTIN3 Protein, PVRL3 Protein, nectin3 Protein
- Sujet
- Poliovirus receptor-related 3 (PVRL3), also known as nectin-3 and CD113, is a human protein of the immunoglobulin superfamily which forms part of adherens junctions. Nectins are immunoglobulin-like adhesion molecules that interact with afadin (AF6, MIM 159559). Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin system in epithelial cells. PVRL3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Furthermore, PVRL3 induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation.
- Poids moléculaire
- 64.3 kDa
- ID gène
- 25945
- NCBI Accession
- NP_056295
- UniProt
- Q9NQS3
- Pathways
- Cell-Cell Junction Organization
-