TIGIT Protein (partial) (Fc Tag)

N° du produit ABIN5608471

Détail du produit

Antigène: TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: partial

Origine: Lapin

Source: HEK-293 Cells

Purification/Conjugué: Cette TIGIT protéine est marqué à la Fc Tag.

Application: Western Blotting (WB), ELISA

Séquence: Ala 16 - Pro 142

Pureté: >95 % as determined by SDS-PAGE.

niveau d'endotoxine: Endotoxin level is less than 1.0 EU per ug by the LAL method.

Biological Activity Comment:

Measured by its binding ability in a functional ELISA. Immobilized Human Nectin-2, His Tag at 5 μg/mL (100 uL/well) can bind Rabbit TIGIT, Fc Tag with a linear range of 5-78 ng/mL (QC tested).

Information d'application

Indications d'application: This recombinant protein can be used for E, WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 50 mM Tris, 100 mM Glycine, pH 7.5

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C,-80 °C

Stockage commentaire: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C.

Détail du antigène

Antigène: TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))

Autre désignation: TIGIT (TIGIT Produits)

Synonymes: VSIG9 Protein, VSTM3 Protein, WUCAM Protein, ENSMUSG00000071552 Protein, Vstm3 Protein, RGD1563191 Protein, T-cell immunoreceptor with Ig and ITIM domains Protein, T cell immunoreceptor with Ig and ITIM domains Protein, TIGIT Protein, Tigit Protein

Sujet: T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

Poids moléculaire: 40.4 kDa

ID gène: 100343230

UniProt: G1SLC1

Pathways: Cancer Immune Checkpoints