EYA2 Protein (AA 1-514, Isoform 2) (His-SUMO Tag)
-
- Antigène Voir toutes EYA2 Protéines
- EYA2 (Eyes Absent Homolog 2 (Drosophila) (EYA2))
- Type de proteíne
- Recombinant
- Attributs du protein
- Isoform 2, AA 1-514
-
Origine
- Humain
-
Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette EYA2 protéine est marqué à la His-SUMO Tag.
- Application
- SDS-PAGE (SDS)
- Séquence
- MVELVISPSL TVNSDCLDKL KFNRADAAVW TLSDRQGITK SAPLRVSQLF SRSCPRVLPR QPSTAMAAYG QTQYSAGIQQ ATPYTAYPPP AQAYGIPSFS TSPTGQSPYT YQMHGTTGFY QGGNGLGNAA GFGSVHQDYP SYPGFPQSQY PQYYGSSYNP PYVPASSICP SPLSTSTYVL QEASHNVPNQ SSESLAGEYN THNGPSTPAK EGDTDRPHRA SDGKLRGRSK RSSDPSPAGD NEIERVFVWD LDETIIIFHS LLTGTFASRY GKDTTTSVRI GLMMEEMIFN LADTHLFFND LEDCDQIHVD DVSSDDNGQD LSTYNFSADG FHSSAPAANL CLGSGVHGGV DWMRKLAFRY RRVKEMYNTY KNNVGGLIGT PKRETWLQLR AELEALTDLW LTHSLKALNL INSRPNCVNV LVTTTQLIPA LAKVLLYGLG SVFPIENIYS ATKTGKESCF ERIMQRFGRK AVYVVIGDGV EEEQGAKKHN MPFWRISCHA DLEALRHALE LEYL
- Purification
- SDS-PAGE
- Pureté
- > 90 %
- Top Product
- Discover our top product EYA2 Protéine
-
Eyes Absent Homolog 2 (Drosophila) (EYA2) (AA 244-514) protein (His tag)
EYA2 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Eyes Absent Homolog 2 (Drosophila) (EYA2) (AA 1-538) protein (GST tag)EYA2 Origine: Humain Hôte: Wheat germ Recombinant ELISA, WB, AA, AP
Eyes Absent Homolog 2 (Drosophila) (EYA2) (AA 1-538) protein (Strep Tag)Crystallography grade EYA2 Origine: Humain Hôte: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB
Eyes Absent Homolog 2 (Drosophila) (EYA2) (AA 1-532) protein (Strep Tag)Crystallography grade EYA2 Origine: Souris Hôte: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB
-
- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Stock
- -80 °C,4 °C,-20 °C
- Stockage commentaire
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
-
- Antigène
- EYA2 (Eyes Absent Homolog 2 (Drosophila) (EYA2))
- Autre désignation
- EYA2 (EYA2 Produits)
- Synonymes
- EYA2 Protein, zgc:92279 Protein, eab1 Protein, Eab1 Protein, EAB1 Protein, EYA transcriptional coactivator and phosphatase 2 Protein, EYA2 Protein, eya2 Protein, Eya2 Protein
- Sujet
- Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2, in this it is functionally redundant with EYA1.
- Poids moléculaire
- 72.7 kDa
- UniProt
- O00167
-
