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POLR3A Protein (AA 392-632, partial) (His-SUMO Tag)

POLR3A Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 90 % SDS
N° du produit ABIN5710123
  • Antigène Voir toutes POLR3A Protéines
    POLR3A (Polymerase (RNA) III (DNA Directed) Polypeptide A, 155kDa (POLR3A))
    Type de proteíne
    Recombinant
    Attributs du protein
    AA 392-632, partial
    Origine
    Humain
    Source
    • 1
    • 1
    Escherichia coli (E. coli)
    Purification/Conjugué
    Cette POLR3A protéine est marqué à la His-SUMO Tag.
    Application
    SDS-PAGE (SDS)
    Séquence
    FPEKVNKANI NFLRKLVQNG PEVHPGANFI QQRHTQMKRF LKYGNREKMA QELKYGDIVE RHLIDGDVVL FNRQPSLHKL SIMAHLARVK PHRTFRFNEC VCTPYNADFD GDEMNLHLPQ TEEAKAEALV LMGTKANLVT PRNGEPLIAA IQDFLTGAYL LTLKDTFFDR AKACQIIASI LVGKDEKIKV RLPPPTILKP VTLWTGKQIF SVILRPSDDN PVRANLRTKG KQYCGKGEDL C
    Purification
    SDS-PAGE
    Pureté
    > 90 %
    Top Product
    Discover our top product POLR3A Protéine
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.1-2 mg/mL
    Buffer
    20 mM Tris-HCl based buffer, pH 8.0
    Stock
    -80 °C,4 °C,-20 °C
    Stockage commentaire
    Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Antigène
    POLR3A (Polymerase (RNA) III (DNA Directed) Polypeptide A, 155kDa (POLR3A))
    Autre désignation
    RPC1 (POLR3A Produits)
    Synonymes
    9330175N20Rik Protein, BC053071 Protein, RPC1 Protein, RPC155 Protein, RGD1305574 Protein, ADDH Protein, HLD7 Protein, hRPC155 Protein, polymerase (RNA) III (DNA directed) polypeptide A Protein, RNA polymerase III subunit A Protein, Polr3a Protein, POLR3A Protein
    Sujet
    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA tplate strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix anates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition . Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as tplate for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
    Poids moléculaire
    43.34 kDa
    UniProt
    O14802
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