Vpx Protein (VPX) (AA 1-113), (full length) protein (His tag)

N° du produit ABIN5710828

Détail du produit

Antigène: Vpx Protein (VPX)

Type de proteíne: Recombinant

Attributs du protein: AA 1-113, full length

Origine: Human Immunodeficiency Virus (HIV)

Source: Escherichia coli (E. coli)

Purification/Conjugué: His tag

Application: SDS-PAGE (SDS)

Séquence: MTDPRERVPP GNSGEETIGE AFEWLERTIE ALNREAVNHL PRELIFQVWQ RSWRYWHDEQ GMSASYTKYR YLCLMQKAIF THFKRGCTCW GEDMGREGLE DQGPPPPPPP GLV

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: Vpx Protein (VPX)

Autre désignation: VPX (VPX Produits)

Synonymes: vpx protein Protein, vpx Protein

Classe de substances: Viral Protein

Sujet: Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription.

Poids moléculaire: 17.3 kDa

UniProt: P18099