SART3 Protein (AA 600-900, partial) (His-SUMO Tag)

N° du produit ABIN5711337

Détail du produit

Antigène: SART3 (Squamous Cell Carcinoma Antigen Recognized By T Cells 3 (SART3))

Type de proteíne: Recombinant

Attributs du protein: AA 600-900, partial

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette SART3 protéine est marqué à la His-SUMO Tag.

Application: SDS-PAGE (SDS)

Séquence: QRKRARAEKK ALKKKKKIRG PEKRGADEDD EKEWGDDEEE QPSKRRRVEN SIPAAGETQN VEVAAGPAGK CAAVDVEPPS KQKEKAASLK RDMPKVLHDS SKDSITVFVS NLPYSMQEPD TKLRPLFEAC GEVVQIRPIF SNRGDFRGYC YVEFKEEKSA LQALEMDRKS VEGRPMFVSP CVDKSKNPDF KVFRYSTSLE KHKLFISGLP FSCTKEELEE ICKAHGTVKD LRLVTNRAGK PKGLAYVEYE NESQASQAVM KMDGMTIKEN IIKVAISNPP QRKVPEKPET RKAPGGPMLL P

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: SART3 (Squamous Cell Carcinoma Antigen Recognized By T Cells 3 (SART3))

Autre désignation: SART3 (SART3 Produits)

Synonymes: SART3 Protein, DKFZp469J2418 Protein, si:ch211-191d15.4 Protein, wu:fc51h03 Protein, DSAP1 Protein, P100 Protein, RP11-13G14 Protein, TIP110 Protein, p110 Protein, p110(nrb) Protein, AU045857 Protein, mKIAA0156 Protein, squamous cell carcinoma antigen recognized by T-cells 3 Protein, squamous cell carcinoma antigen recognized by T-cells 3 L homeolog Protein, squamous cell carcinoma antigen recognized by T cells 3 Protein, SART3 Protein, sart3 Protein, sart3.L Protein, Sart3 Protein

Sujet: U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassbly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation . Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assbly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites . May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassbly . May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair . May play a role in hatopoiesis probably through transcription regulation of specific genes including MYC .

Poids moléculaire: 49.82 kDa

UniProt: Q15020

Pathways: Ribonucleoprotein Complex Subunit Organization