WDR77 Protein (AA 1-312, partial) (His-SUMO Tag)

N° du produit ABIN5711731

Détail du produit

Antigène: WDR77 (WD Repeat Domain 77 (WDR77))

Type de proteíne: Recombinant

Attributs du protein: AA 1-312, partial

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette WDR77 protéine est marqué à la His-SUMO Tag.

Application: SDS-PAGE (SDS)

Séquence: MRKETPPPLV PPAAREWNLP PNAPACMERQ LEAARYRSDG ALLLGASSLS GRCWAGSLWL FKDPCAAPNE GFCSAGVQTE AGVADLTWVG ERGILVASDS GAVELWELDE NETLIVSKFC KYEHDDIVST VSVLSSGTQA VSGSKDICIK VWDLAQQVVL SSYRAHAAQV TCVAASPHKD SVFLSCSEDN RILLWDTRCP KPASQIGCSA PGYLPTSLAW HPQQSEVFVF GDENGTVSLV DTKSTSCVLS SAVHSQCVTG LVFSPHSVPF LASLSEDCSL AVLDSSLSEL FRSQAHRDFV RDATWSPLNH SL

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: WDR77 (WD Repeat Domain 77 (WDR77))

Autre désignation: MEP50 (WDR77 Produits)

Synonymes: MEP-50 Protein, MEP50 Protein, Nbla10071 Protein, RP11-552M11.3 Protein, p44 Protein, p44/Mep50 Protein, 2610003I18Rik Protein, 2610312E17Rik Protein, C79984 Protein, p44/MEP50 Protein, RGD1310479 Protein, mep50 Protein, valois Protein, WDR77 Protein, zgc:65780 Protein, zgc:77274 Protein, WD repeat domain 77 Protein, WD repeat domain 77 S homeolog Protein, WDR77 Protein, Wdr77 Protein, wdr77.S Protein, wdr77 Protein

Sujet: Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assbly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.

Poids moléculaire: 49.5 kDa

UniProt: Q9BQA1

Pathways: Ribonucleoprotein Complex Subunit Organization