GPR161 Protein (AA 1-28, Extracellular, partial) (GST tag)

N° du produit ABIN5712333

Détail du produit

Antigène: GPR161 (G Protein-Coupled Receptor 161 (GPR161))

Type de proteíne: Recombinant

Attributs du protein: Extracellular, AA 1-28, partial

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette GPR161 protéine est marqué à la GST tag.

Application: SDS-PAGE (SDS)

Séquence: MSLNSSLSCR KELSNLTEEE GGEGGVII

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: GPR161 (G Protein-Coupled Receptor 161 (GPR161))

Autre désignation: GP161 (GPR161 Produits)

Synonymes: RE2 Protein, Gm208 Protein, Gm208Gpr Protein, vl Protein, RGD1563245 Protein, si:bz20i5.4 Protein, si:rp71-20i5.4 Protein, G protein-coupled receptor 161 Protein, GPR161 Protein, Gpr161 Protein, gpr161 Protein

Sujet: Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is roved from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown .

Poids moléculaire: 30.4 kDa

UniProt: Q8N6U8

Pathways: cAMP Metabolic Process