LOXL2 Protein (AA 26-776) (His tag)

N° du produit ABIN5713616

Détail du produit

Antigène: LOXL2 (Lysyl Oxidase-Like 2 (LOXL2))

Type de proteíne: Recombinant

Attributs du protein: AA 26-776

Origine: Souris

Source: Levure

Purification/Conjugué: Cette LOXL2 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: QYEGWPYQLQ YPEYFQQPAP EHHQRQVPSD VVKIQVRLAG QKRKHNEGRV EVYYEGQWGT VCDDDFSIHA AHVVCRQVGY VEAKSWAASS SYGPGEGPIW LDNIYCTGKE STLASCSSNG WGVTDCKHTE DVGVVCSEKR IPGFKFDNSL INQIESLNIQ VEDIRIRPIL SAFRHRKPVT EGYVEVKEGK AWKQICNKHW TAKNSHVVCG MFGFPAEKTY NPKAYKTFAS RRKLRYWKFS MNCTGTEAHI SSCKLGPSVT RDPVKNATCE NGQPAVVSCV PSQIFSPDGP SRFRKAYKPE QPLVRLRGGA QVGEGRVEVL KNGEWGTICD DKWDLVSASV VCRELGFGTA KEAITGSRLG QGIGPIHLNE VQCTGTEKSI IDCKFNTESQ GCNHEEDAGV RCNIPIMGFQ KKVRLNGGRN PYEGRVEVLT ERNGSLVWGT VCGQNWGIVE AMVVCRQLGL GFASNAFQET WYWHGNIFAN NVVMSGVKCS GTELSLAHCR HDEEVACPEG GVRFGAGVAC SETAPDLVLN AEIVQQTAYL EDRPMSLLQC AMEENCLSAS AVHTDPTRGH RRLLRFSSQI HNNGQSDFRP KNGRHAWIWH DCHRHYHSME VFTYYDLLSL NGTKVAEGHK ASFCLEDTEC EGDIQKSYEC ANFGEQGITM GCWDMYRHDI DCQWIDITDV PPGDYLFQVV INPNYEVPES DFSNNIMKCR SRYDGYRIWM YNCHVGGAFS EETEQKFEHF SGLLNNQLSV Q

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: LOXL2 (Lysyl Oxidase-Like 2 (LOXL2))

Autre désignation: LOXL2 (LOXL2 Produits)

Synonymes: LOR2 Protein, WS9-14 Protein, CG4402 Protein, Dmel\\CG4402 Protein, Dmloxl-2 Protein, dmlox-2 Protein, 1110004B06Rik Protein, 4930526G11Rik Protein, 9430067E15Rik Protein, GB13360 Protein, lox2-like Protein, LOXL2 Protein, lor2 Protein, loxl-2 Protein, ws9-14 Protein, im:7136137 Protein, si:dkeyp-32b1.1 Protein, wu:fk12g04 Protein, zgc:158414 Protein, lysyl oxidase like 2 Protein, lysyl oxidase-like 2 Protein, lysyl oxidase homolog 4 Protein, lysyl oxidase like 2 L homeolog Protein, lysyl oxidase-like 2b Protein, LOXL2 Protein, lox2 Protein, Loxl2 Protein, LOC408544 Protein, loxl2.L Protein, loxl2 Protein, loxl2b Protein

Sujet: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (T) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3 . Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.1 Publication

Poids moléculaire: 86.43 kDa

UniProt: P58022

Pathways: Chromatin Binding