TEAD1 Protein (AA 1-426, full length) (His tag)

N° du produit ABIN5713882

Détail du produit

Antigène: TEAD1 (TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor) (TEAD1))

Type de proteíne: Recombinant

Attributs du protein: full length, AA 1-426

Origine: Humain

Source: Levure

Purification/Conjugué: Cette TEAD1 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: MEPSSWSGSE SPAENMERMS DSADKPIDND AEGVWSPDIE QSFQEALAIY PPCGRRKIIL SDEGKMYGRN ELIARYIKLR TGKTRTRKQV SSHIQVLARR KSRDFHSKLK DQTAKDKALQ HMAAMSSAQI VSATAIHNKL GLPGIPRPTF PGAPGFWPGM IQTGQPGSSQ DVKPFVQQAY PIQPAVTAPI PGFEPASAPA PSVPAWQGRS IGTTKLRLVE FSAFLEQQRD PDSYNKHLFV HIGHANHSYS DPLLESVDIR QIYDKFPEKK GGLKELFGKG PQNAFFLVKF WADLNCNIQD DAGAFYGVTS QYESSENMTV TCSTKVCSFG KQVVEKVETE YARFENGRFV YRINRSPMCE YMINFIHKLK HLPEKYMMNS VLENFTILLV VTNRDTQETL LCMACVFEVS NSEHGAQHHI YRLVKD

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: TEAD1 (TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor) (TEAD1))

Autre désignation: TEAD1 (TEAD1 Produits)

Synonymes: tead1 Protein, zgc:63696 Protein, TEAD1 Protein, xtead1 Protein, 2610024B07Rik Protein, B230114H05Rik Protein, Gtrgeo5 Protein, TEAD-1 Protein, TEF-1 Protein, Tcf13 Protein, mTEF-1 Protein, AA Protein, NTEF-1 Protein, REF1 Protein, TCF-13 Protein, TCF13 Protein, XNTEF-1 Protein, xlNTEF-1 Protein, TEA domain family member 1a Protein, TEA domain transcription factor 1 Protein, TEA domain family member 1 (SV40 transcriptional enhancer factor) Protein, TEA domain family member 1 Protein, TEA domain family member 1 (SV40 transcriptional enhancer factor) S homeolog Protein, TEA domain family member 1b Protein, tead1a Protein, TEAD1 Protein, tead1 Protein, Tead1 Protein, tead1.S Protein, tead1b Protein

Sujet: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (T) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.

Poids moléculaire: 49.95 kDa

UniProt: P28347

Pathways: Regulation of Lipid Metabolism by PPARalpha