RAPSN Protein (AA 1-412) (His tag)

N° du produit ABIN5853342

Détail du produit

Antigène: RAPSN (Receptor-Associated Protein of The Synapse (RAPSN))

Type de proteíne: Recombinant

Attributs du protein: AA 1-412

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette RAPSN protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: MGSSHHHHHH SSGLVPRGSH MGSMGQDQTK QQIEKGLQLY QSNQTEKALQ VWMKVLEKGS DLVGRFRVLG CLVTAHSEMG RYKEMLKFAV VQIDTARGLE DADFLLESYL NLARSNEKLC EFHKTISYCK TCLGLPGTRA GAQLGGQVSL SMGNAFLGLS LFQKALESFE KALRYAHNND DTMLECRVCC SLGSFYAQVK DYEKALFFPC KAAELVNDYG KGWSLKYRAM SQYHMAVAYR LLGHLGSAME CCEESMKIAL QHGDRPLQAL CLLCFADIHR SRGDLETAFP RYDSAMSIMT EIGNRLGQVH VLLGVAKCWM ARKVQDKALD AIEKAQDLAE EVGNKLSQLK LHCLSESIYR SKGLQRELRT HVVRFHECVE ETELYCGLCG ESIGERNSRL QALPCSHIFH LRCLQNNGTR SCPNCRRSSM KPGFV

Pureté: > 85 % by SDS - PAGE

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Denatured

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Liquid. 20  mM Tris-HCl buffer (  pH 8.0) containing 10 % glycerol 0.4M urea

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: RAPSN (Receptor-Associated Protein of The Synapse (RAPSN))

Autre désignation: RAPSN (RAPSN Produits)

Synonymes: RAPSN Protein, RAPSYN Protein, RNF205 Protein, 43kDa Protein, Nraps Protein, Raps Protein, rapsyn Protein, receptor associated protein of the synapse Protein, receptor associated protein of the synapse S homeolog Protein, receptor-associated protein of the synapse Protein, receptor-associated protein of the synapse, 43kD Protein, RAPSN Protein, rapsn.S Protein, Rapsn Protein, rapsn Protein

Sujet: 43 kDa receptor-associated protein of the synapse, also known as RAPSN, is expressed in the postsynaptic membrane of skeletal muscle. RAPSN is required for the clustering of nicotinic acetylcholine receptors (nAChR). It self-associates through at least two of its seven tetra-tricopeptide repeats (TPRs). RAPSN interacts with the large intracellular domain of the nAChR a subunit through the hydrophobic surface of the coiled-coil domain. This protein modifies trafficking of AChR within the cell. Overexpression inhibits agrin-induced AChR clustering pathway. Recombinant human RAPSN protein, fused to His-tag at N-terminus, was expressed in E.coli.

Poids moléculaire: 48.8 kDa (435aa)

NCBI Accession: NP_033049

UniProt: P12672