WWTR1 Protein (AA 1-400) (His tag)

N° du produit ABIN5853441

Détail du produit

Antigène: WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))

Type de proteíne: Recombinant

Attributs du protein: AA 1-400

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette WWTR1 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: MGSSHHHHHH SSGLVPRGSH MGSMNPASAP PPLPPPGQQV IHVTQDLDTD LEALFNSVMN PKPSSWRKKI LPESFFKEPD SGSHSRQSST DSSGGHPGPR LAGGAQHVRS HSSPASLQLG TGAGAAGSPA QQHAHLRQQS YDVTDELPLP PGWEMTFTAT GQRYFLNHIE KITTWQDPRK AMNQPLNHMN LHPAVSSTPV PQRSMAVSQP NLVMNHQHQQ QMAPSTLSQQ NHPTQNPPAG LMSMPNALTT QQQQQQKLRL QRIQMERERI RMRQEELMRQ EAALCRQLPM EAETLAPVQA AVNPPTMTPD MRSITNNSSD PFLNGGPYHS REQSTDSGLG LGCYSVPTTP EDFLSNVDEM DTGENAGQTP MNINPQQTRF PDFLDCLPGT NVDLGTLESE DLIPLFNDVE SALNKSEPFL TWL

Pureté: > 85 % by SDS - PAGE

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Denatured

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 0.4M uREA, 10 % glycerol

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))

Autre désignation: WWTR1 (WWTR1 Produits)

Synonymes: WWTR1 Protein, TAZ Protein, 2310058J06Rik Protein, 2610021I22Rik Protein, C78399 Protein, Taz Protein, WW domain containing transcription regulator 1 L homeolog Protein, WW domain containing transcription regulator 1 Protein, wwtr1.L Protein, wwtr1 Protein, WWTR1 Protein, Wwtr1 Protein

Sujet: WWTR1 is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Recombinant human WWTR1 protein, fused to His-tag at N-terminus, was expressed in E.coli .

Poids moléculaire: 46.5kDa (423aa)

NCBI Accession: NP_001161752

UniProt: Q9GZV5

Pathways: Regulation of Lipid Metabolism by PPARalpha