PEBP1 Protein (AA 1-187) (His tag)

N° du produit ABIN5854348

Détail du produit

Antigène: PEBP1 (Phosphatidylethanolamine Binding Protein 1 (PEBP1))

Type de proteíne: Recombinant

Attributs du protein: AA 1-187

Origine: Souris

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette PEBP1 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: MGSSHHHHHH SSGLVPRGSH MGSMAADISQ WAGPLCLQEV DEPPQHALRV DYAGVTVDEL GKVLTPTQVM NRPSSISWDG LDPGKLYTLV LTDPDAPSRK DPKFREWHHF LVVNMKGNDI SSGTVLSDYV GSGPPSGTGL HRYVWLVYEQ EQPLSCDEPI LSNKSGDNRG KFKVETFRKK YNLGAPVAGT CYQAEWDDYV PKLYEQLSGK

Pureté: > 95 % by SDS - PAGE

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. In Phosphate Buffered Saline (  pH 7.4) containing 10 % glycerol

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: PEBP1 (Phosphatidylethanolamine Binding Protein 1 (PEBP1))

Autre désignation: Pebp1 (PEBP1 Produits)

Synonymes: HCNP Protein, HCNPpp Protein, PBP Protein, PEBP Protein, PEBP-1 Protein, RKIP Protein, pbp Protein, hcnp Protein, pebp Protein, rkip Protein, Pbp Protein, Pbp1 Protein, Pbpr Protein, Rkip Protein, PEBP1 Protein, BcDNA:LP12095 Protein, CG18594 Protein, Dmel\\CG18594 Protein, T2 Protein, zgc:56033 Protein, zgc:76942 Protein, phosphatidylethanolamine binding protein 1 Protein, phosphatidylethanolamine binding protein 1 L homeolog Protein, phosphatidylethanolamine-binding protein Protein, phosphatidylethanolamine-binding protein,putative Protein, Phosphatidylethanolamine-binding protein 1 Protein, PEBP1 Protein, pebp1 Protein, Pebp1 Protein, pebp1.L Protein, RR_RS07785 Protein, PVX_235290 Protein, PVX_123630 Protein, PKH_143640 Protein, EAM_1207 Protein

Sujet: Pebp1 also known as Phosphatidylethanolamine-binding protein 1. The protein Binds with ATP, opioids and phosphatidylethanolamine. Pebp1 exerts inhibitory activity against several serine proteases including thrombin, neuropsin, and chymotrypsin, it also inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. Also, targeting Pebp1 levels can delay photoreceptor degeneration, assisting in extending the time-window for treating such rapidly progressing blindness disorder. Recombinant mouse Pebp1, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Poids moléculaire: 23.2kDa (210aa) confirmed by MALDI-TOF

NCBI Accession: NP_061346

UniProt: P70296

Pathways: Feeding Behaviour