VHLL Protein (AA 1-154) (His tag)

N° du produit ABIN620853

Détail du produit

Antigène: VHLL (Von Hippel-Lindau Tumor Suppressor-Like (VHLL))

Type de proteíne: Recombinant

Attributs du protein: AA 1-154

Origine: Humain

Hôte: Veuillez nous consulter SVP

Purification/Conjugué: Cette VHLL protéine est marqué à la His tag.

Séquence: MGSSHHHHHH SSGLVPRGSH MPRRAENWDE AEVGAEEAGV EEYGPEEDGG EESGAEESGPEESGPEELGA EEEMEAGRPR PVLRSVNSRE PSQVIFCNRS PRVVLPVWLN FDGEPQPYPT LPPGTGRRIH SYRGHLWLFR DAGTHDGLLV NQTELFVPSL NVDGQPIFAN ITLP.

Attributs du produit: Recombinant Human Von Hippel-Lindau Protein

Pureté: > 95.0 % as determined by SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: The Von Hippel-Lindau Protein contains 1x PBS pH-7.4, 2mM EDTA, and 1mM DTT.

Stock: 4 °C

Détail du antigène

Antigène: VHLL (Von Hippel-Lindau Tumor Suppressor-Like (VHLL))

Autre désignation: Von Hippel-Lindau Protein (VHLL Produits)

Synonymes: VHLP Protein, VLP Protein, VHL like Protein, VHLL Protein

Sujet: Recombinant Human Von Hippel-Lindau Protein b-domain produced in E. coli is a single, non-glycosylated polypeptide chain containing 174 AA (1-154) and having a molecular mass of 19.2 kDa. The Von Hippel-Lindau antigen is fused to 20 AA His-Tag at N-terminus and purified by proprietary chromatography techniques. Introduction: Von Hippel-Lindau disease is a dominant inherited syndrome characterized by the predisposition to develop various kinds of benign and malignant tumors, including clear cell renal carcinomas, pheochromocytomas and hemangioblastomas of the central nervous system and retina. VHL syndrome is caused by germline mutation in the VHL tumor suppressor, and VHL tumors are associated with loss or mutation of the remaining wild-type allele. VHL has two domains: a roughly 100-residue NH2-terminal domain rich in b sheet (b-domain) and a smaller a-helical domain (a-domain), held together by two linkers and a polar interface. VHL protein is also involved in the degradation of hypoxia-inducible factor (HIF). Synonyms: Von Hippel-Lindau disease tumor suppressor, pVHL, Protein G7, VHL, RCA1, VHL1, HRCA1.