ICAM1 Protein (AA 28-485) (Fc Tag)

N° du produit ABIN6253322

Détail du produit

Antigène: ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))

Type de proteíne: Recombinant

Attributs du protein: AA 28-485

Origine: Souris

Source: CHO Cells

Purification/Conjugué: Cette ICAM1 protéine est marqué à la Fc Tag.

Fonction: CD54 [ICAM-1] (mouse):Fc (mouse) (rec.) (non-lytic)

Specificité: The extracellular domain of mouse CD54 [ICAM-1] (aa 28-485) is fused to the N-terminus of the Fc region of a mutant mouse IgG2a.

Attributs du produit: Protein. The extracellular domain of mouse CD54 [ICAM-1] (aa 28-485) is fused to the N-terminus of the Fc region of a mutant mouse IgG2a. Source: CHO cells. Endotoxin content: <0.06EU/μg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). Intercellular Adhesion Molecule-1 (ICAM-1, CD54) binds the leukocyte integrins LFA-1 and Mac1. CD54 expression is weak on leukocytes, epithelial and resting endothelial cells, as well as some other cell types, but expression can be stimulated by IFN-gamma, TNF-alpha, IL-1beta and LPS. Soluble CD54 is found in a biologically active form in serum, probably as a result of proteolytic cleavage from the cell surface, and is elevated in patients with various inflammatory syndromes such as septic shock, LAD, cancer and transplantation.

Pureté: >98 % (SDS-PAGE)

niveau d'endotoxine: <0.06EU/μg protein (LAL test, Lonza).

Biological Activity Comment: Shows the biological function of the CD54 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized from 0.2μm-filtered solution in PBS.

Conseil sur la manipulation: Avoid freeze/thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Détail du antigène

Antigène: ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))

Autre désignation: CD54 [ICAM-1] (ICAM1 Produits)

Synonymes: BB2 Protein, CD54 Protein, P3.58 Protein, Icam-1 Protein, Ly-47 Protein, MALA-2 Protein, ICAM Protein, ICAM-1 Protein, ICAM1 Protein, intercellular adhesion molecule 1 Protein, intercellular adhesion molecule-1 Protein, ICAM1 Protein, Icam1 Protein, ICAM-1 Protein

Classe de substances: Viral Protein

Sujet:

Alternate Names/Synonyms: ICAM1, Intercellular Adhesion Molecule 1

Product Description: Intercellular Adhesion Molecule-1 (ICAM-1, CD54) binds the leukocyte integrins LFA-1 and Mac1. CD54 expression is weak on leukocytes, epithelial and resting endothelial cells, as well as some other cell types, but expression can be stimulated by IFN-gamma, TNF-alpha, IL-1beta and LPS. Soluble CD54 is found in a biologically active form in serum, probably as a result of proteolytic cleavage from the cell surface, and is elevated in patients with various inflammatory syndromes such as septic shock, LAD, cancer and transplantation.

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Regulation of Leukocyte Mediated Immunity, Thromboxane A2 Receptor Signaling