Galectin 9 Protein (AA 2-323) (Fc Tag)

N° du produit ABIN6253400

Détail du produit

Antigène: Galectin 9 (LGALS9) (Lectin, Galactoside-Binding, Soluble, 9 (LGALS9))

Type de proteíne: Recombinant

Attributs du protein: AA 2-323

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette Galectin 9 protéine est marqué à la Fc Tag.

Fonction: Galectin-9 (human):Fc (human) (rec.)

Specificité: The extracellular domain of human Galectin-9 (aa 2-323) is fused to the N-terminus of the Fc region of human IgG1.

Attributs du produit: Protein. The extracellular domain of human Galectin-9 (aa 2-323) is fused to the N-terminus of the Fc region of human IgG1. Source: HEK 293 cells. Endotoxin content: <5EU/mg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >95 % (SDS-PAGE). The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. Tim-3, a type I transmembrane protein, contains an immunoglobulin and a mucin-like domain in its extracellular portion and a tyrosine phosphorylation motif in its cytoplasmic portion. TIM-3 is preferentially expressed on Th1 and Tc1 cells, and generates an inhibitory signal resulting in apoptosis of Th1 and Tc1 cells. TIM-3 is also expressed on some dendritic cells and can mediate phagocytosis of apoptotic cells and cross-presentation of antigen. Tim-3 functions to inhibit aggressive Th1-mediated auto- and alloimmune responses. Tim-3 pathway blockade by administration of Tim-3:Fc fusion protein accelerates diabetes in nonobese diabetic mice, causes hyperproliferation of Th1 cells and Th1 cytokine release in an experimental autoimmune encephalomyelitis (EAE) model and prevents acquisition of transplantation tolerance induced by costimulation blockade.

Pureté: >95 % (SDS-PAGE)

niveau d'endotoxine: <5EU/mg protein (LAL test, Lonza).

Biological Activity Comment: Measured by its binding ability in a functional ELISA.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized from 0.2μm-filtered solution in PBS.

Conseil sur la manipulation: Avoid freeze/thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Détail du antigène

Antigène: Galectin 9 (LGALS9) (Lectin, Galactoside-Binding, Soluble, 9 (LGALS9))

Autre désignation: Galectin-9 (LGALS9 Produits)

Synonymes: huat Protein, lgals9a Protein, ecalectin Protein, galectin-9 Protein, Lgals9 Protein, wu:fd20c09 Protein, zgc:111833 Protein, LGALS9 Protein, AA407335 Protein, AI194909 Protein, AI265545 Protein, LGALS35 Protein, Lgals5 Protein, gal-9 Protein, HUAT Protein, LGALS9A Protein, UAT Protein, UATP.I Protein, galectin 9 L homeolog Protein, galectin 9 Protein, lectin, galactoside-binding, soluble, 9 (galectin 9)-like 3 Protein, lectin, galactose binding, soluble 9 Protein, lgals9.L Protein, lgals9 Protein, lgals9l3 Protein, LGALS9 Protein, Lgals9 Protein

Sujet:

Alternate Names/Synonyms: Gal-9, Ecalectin, TIM3L, TIM-3 Ligand, T Cell Immunoglobulin and Mucin Domain-containing Protein 3 Ligand

Product Description: The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. Tim-3, a type I transmembrane protein, contains an immunoglobulin and a mucin-like domain in its extracellular portion and a tyrosine phosphorylation motif in its cytoplasmic portion. TIM-3 is preferentially expressed on Th1 and Tc1 cells, and generates an inhibitory signal resulting in apoptosis of Th1 and Tc1 cells. TIM-3 is also expressed on some dendritic cells and can mediate phagocytosis of apoptotic cells and cross-presentation of antigen. Tim-3 functions to inhibit aggressive Th1-mediated auto- and alloimmune responses. Tim-3 pathway blockade by administration of Tim-3:Fc fusion protein accelerates diabetes in nonobese diabetic mice, causes hyperproliferation of Th1 cells and Th1 cytokine release in an experimental autoimmune encephalomyelitis (EAE) model and prevents acquisition of transplantation tolerance induced by costimulation blockade.

Poids moléculaire: ~70kDa (SDS-PAGE)