BTNL2 Protein (AA 26-457) (Fc Tag)

N° du produit ABIN6253435

Détail du produit

Antigène: BTNL2 (Butyrophilin-Like 2 (MHC Class II Associated) (BTNL2))

Type de proteíne: Recombinant

Attributs du protein: AA 26-457

Origine: Souris

Source: CHO Cells

Purification/Conjugué: Cette BTNL2 protéine est marqué à la Fc Tag.

Fonction: BTNL2 (mouse):Fc (mouse) (rec.)

Specificité: The extracellular domain of mouse BTNL2 (aa 26-457) is fused to the N-terminus of the Fc region of mouse IgG2a.

Attributs du produit: Protein. The extracellular domain of mouse BTNL2 (aa 26-457) is fused to the N-terminus of the Fc region of mouse IgG2a. Source: CHO cells. Endotoxin content: <0.06EU/μg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). Butyrophilin-like 2 (BTNL2) is a butyrophilin family member with homology to the B7 costimulatory molecules, polymorphisms of which have been recently associated through genetic analysis, to sporadic inclusion body myositis and sarcoidosis. BTNL2 mRNA is highly expressed in lymphoid tissues as well as in intestine. BTNL2-Ig fusion protein was shown to recognize a putative receptor whose expression on B and T cells was significantly enhanced after activation. It inhibited T cell proliferation and TCR activation of NFAT, NF-kappaB and AP-1 signaling pathways. BTNL2 is the first member of the butyrophilin family that regulates T cell activation, which has implications in immune diseases and immunotherapy.

Pureté: >98 % (SDS-PAGE)

niveau d'endotoxine: <0.06EU/μg protein (LAL test, Lonza).

Biological Activity Comment: A butyrophilin-like molecule that functions to inhibit T cell activation.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized from 0.2μm-filtered solution in PBS.

Conseil sur la manipulation: Avoid freeze/thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Détail du antigène

Antigène: BTNL2 (Butyrophilin-Like 2 (MHC Class II Associated) (BTNL2))

Autre désignation: BTNL2 (BTNL2 Produits)

Synonymes: BTL-II Protein, HSBLMHC1 Protein, SS2 Protein, Ng9 Protein, BTLN2 Protein, Btl2 Protein, Gm315 Protein, NG9 Protein, BTNL2 Protein, butyrophilin like 2 Protein, butyrophilin-like 2 Protein, butyrophilin-like 2 (MHC class II associated) Protein, butyrophilin-like protein 2 Protein, BTNL2 Protein, Btnl2 Protein, LOC100348151 Protein

Sujet:

Alternate Names/Synonyms: Butyrophilin-like Protein 2

Product Description: Butyrophilin-like 2 (BTNL2) is a butyrophilin family member with homology to the B7 costimulatory molecules, polymorphisms of which have been recently associated through genetic analysis, to sporadic inclusion body myositis and sarcoidosis. BTNL2 mRNA is highly expressed in lymphoid tissues as well as in intestine. BTNL2-Ig fusion protein was shown to recognize a putative receptor whose expression on B and T cells was significantly enhanced after activation. It inhibited T cell proliferation and TCR activation of NFAT, NF-kappaB and AP-1 signaling pathways. BTNL2 is the first member of the butyrophilin family that regulates T cell activation, which has implications in immune diseases and immunotherapy.

NCBI Accession: NP_524574